Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1001467..1002054 Replicon chromosome
Accession NZ_CP053350
Organism Winogradskyella forsetii strain SW133

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HM989_RS04375 Protein ID WP_179019694.1
Coordinates 1001755..1002054 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HM989_RS04370 Protein ID WP_179019692.1
Coordinates 1001467..1001751 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HM989_RS04345 996527..997348 - 822 WP_179019681.1 sulfurtransferase -
HM989_RS04350 997348..998793 - 1446 WP_179019683.1 dicarboxylate/amino acid:cation symporter -
HM989_RS04355 998894..999151 - 258 WP_179019685.1 hypothetical protein -
HM989_RS04360 999245..1000315 - 1071 WP_179019687.1 chorismate synthase -
HM989_RS04365 1000524..1001390 + 867 WP_179019689.1 UDP-2,3-diacylglucosamine diphosphatase -
HM989_RS04370 1001467..1001751 - 285 WP_179019692.1 putative addiction module antidote protein Antitoxin
HM989_RS04375 1001755..1002054 - 300 WP_179019694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HM989_RS04380 1002228..1005206 - 2979 WP_179019696.1 FAD-binding oxidoreductase -
HM989_RS04385 1005347..1005850 + 504 WP_179007336.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11758.85 Da        Isoelectric Point: 10.6056

>T156634 WP_179019694.1 NZ_CP053350:c1002054-1001755 [Winogradskyella forsetii]
MFFIEKTNEFDKWLRKLRDFKAKAKILFRVQKLETDEHFGDCKTVGDGIREMRINFAKGYRVYFKEKDGKVIVLLIGGNK
STQQKDIAKAKEIWKKLNK

Download         Length: 300 bp

>T156634 NZ_CP069068:c2230827-2230408 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10084.60 Da        Isoelectric Point: 5.0351

>AT156634 WP_179019692.1 NZ_CP053350:c1001751-1001467 [Winogradskyella forsetii]
MGTSKFEIADYLDSKEMIAEYLNTVLEEGNNTDIINAIGHIAKAIGMTKIAEETGLSRPSLYKALSDGAKPQFATIMKVL
KAIGGQIQVNPTSP

Download         Length: 285 bp

>AT156634 NZ_CP069068:c2231096-2230836 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References