Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3699100..3699659 Replicon chromosome
Accession NZ_CP053346
Organism Sphingomonas sp. AP4-R1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HL653_RS16935 Protein ID WP_171745558.1
Coordinates 3699288..3699659 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HL653_RS16930 Protein ID WP_171745557.1
Coordinates 3699100..3699285 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL653_RS16915 3694631..3695695 - 1065 WP_171745554.1 carotenoid 1,2-hydratase -
HL653_RS16920 3695695..3698193 - 2499 WP_171745555.1 ABC transporter permease -
HL653_RS16925 3698196..3698870 - 675 WP_171745556.1 ABC transporter ATP-binding protein -
HL653_RS16930 3699100..3699285 + 186 WP_171745557.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HL653_RS16935 3699288..3699659 + 372 WP_171745558.1 type II toxin-antitoxin system VapC family toxin Toxin
HL653_RS16940 3699626..3699885 - 260 Protein_3345 hypothetical protein -
HL653_RS16945 3699882..3700877 - 996 WP_171745559.1 LacI family DNA-binding transcriptional regulator -
HL653_RS16950 3700894..3702027 - 1134 WP_171745560.1 gluconolactonase -
HL653_RS16955 3702032..3703096 - 1065 WP_171745561.1 aldo/keto reductase -
HL653_RS16960 3703141..3704487 - 1347 WP_171745562.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13814.93 Da        Isoelectric Point: 6.7596

>T156633 WP_171745558.1 NZ_CP053346:3699288-3699659 [Sphingomonas sp. AP4-R1]
MILVDTSVWVDHLRHGDQTLSNLLQARQIMVHPFVIGELALGSLRQREVVLGALRNLPHSLVASDGEAQIVIERHKLYGS
GIGYVDVHLIAATFLTADVKLWTRDKRLREISIQLERDASLDN

Download         Length: 372 bp

>T156633 NZ_CP069068:c2210420-2210124 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6736.81 Da        Isoelectric Point: 10.4525

>AT156633 WP_171745557.1 NZ_CP053346:3699100-3699285 [Sphingomonas sp. AP4-R1]
MRTTIALDDELVSKAQAFTGLMEKSSLVREALKALIERESALRLARLGGSEPEVTAPPRRR

Download         Length: 186 bp

>AT156633 NZ_CP069068:c2210668-2210417 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References