Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 1747881..1748409 Replicon chromosome
Accession NZ_CP053346
Organism Sphingomonas sp. AP4-R1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HL653_RS08325 Protein ID WP_171744109.1
Coordinates 1748119..1748409 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HL653_RS08320 Protein ID WP_171744108.1
Coordinates 1747881..1748126 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL653_RS08300 1743509..1744018 - 510 WP_171744104.1 YbjN domain-containing protein -
HL653_RS08305 1744120..1744413 - 294 WP_171744105.1 accessory factor UbiK family protein -
HL653_RS08310 1744692..1746788 - 2097 WP_171744106.1 malate synthase G -
HL653_RS08315 1746894..1747784 + 891 WP_171744107.1 LysR family transcriptional regulator -
HL653_RS08320 1747881..1748126 + 246 WP_171744108.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HL653_RS08325 1748119..1748409 + 291 WP_171744109.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HL653_RS08330 1748508..1748993 - 486 WP_171744110.1 hypothetical protein -
HL653_RS08335 1748986..1749543 - 558 WP_171744111.1 sigma-70 family RNA polymerase sigma factor -
HL653_RS08340 1749669..1750235 - 567 WP_171744112.1 helix-turn-helix domain-containing protein -
HL653_RS08345 1750437..1750874 + 438 WP_171746855.1 hypothetical protein -
HL653_RS08350 1750871..1751611 + 741 WP_171744113.1 TlyA family RNA methyltransferase -
HL653_RS08355 1751732..1752949 - 1218 WP_171744114.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(7-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11013.54 Da        Isoelectric Point: 8.5207

>T156631 WP_171744109.1 NZ_CP053346:1748119-1748409 [Sphingomonas sp. AP4-R1]
MADYRLSPRAQRDLEAVFDYTAHHWGLAQAMRYTDLIEAACADLAEAPQHAQDCSHIRPGYRRRGIGQHVIYFRPTGFGI
AVVRVLHQRMDVARHL

Download         Length: 291 bp

>T156631 NZ_CP069068:c2201416-2201087 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9292.29 Da        Isoelectric Point: 5.7202

>AT156631 WP_171744108.1 NZ_CP053346:1747881-1748126 [Sphingomonas sp. AP4-R1]
MATVRKTITLTEQQNAWIAAQIEAGHYTNDSEAIRDLIRREQERSAEIESIRHALIDGEQSGEPERFDFAAFKRRKAAQY
G

Download         Length: 246 bp

>AT156631 NZ_CP069068:c2201790-2201413 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References