Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 714847..715454 Replicon chromosome
Accession NZ_CP053346
Organism Sphingomonas sp. AP4-R1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HL653_RS03475 Protein ID WP_171743276.1
Coordinates 714847..715152 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HL653_RS03480 Protein ID WP_171743277.1
Coordinates 715149..715454 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL653_RS03450 710150..711502 + 1353 WP_171743272.1 hypothetical protein -
HL653_RS03455 711582..712508 + 927 WP_171743273.1 phosphotransferase -
HL653_RS03460 712600..713070 + 471 WP_171743274.1 GFA family protein -
HL653_RS03465 713133..714149 - 1017 WP_171743275.1 hypothetical protein -
HL653_RS03470 714277..714718 - 442 Protein_684 GNAT family N-acetyltransferase -
HL653_RS03475 714847..715152 - 306 WP_171743276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HL653_RS03480 715149..715454 - 306 WP_171743277.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HL653_RS03485 716002..716217 + 216 WP_021316615.1 AlpA family phage regulatory protein -
HL653_RS03490 716214..716408 + 195 WP_171743278.1 helix-turn-helix domain-containing protein -
HL653_RS03495 716383..717621 - 1239 WP_171746754.1 site-specific integrase -
HL653_RS03500 718132..719148 + 1017 WP_171743279.1 zinc-dependent alcohol dehydrogenase family protein -
HL653_RS03505 719259..720089 + 831 WP_171743280.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 676914..717810 40896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-59)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11394.02 Da        Isoelectric Point: 6.4678

>T156630 WP_171743276.1 NZ_CP053346:c715152-714847 [Sphingomonas sp. AP4-R1]
MKLAWSNRAATDRMAIFVWIAEDNPQAAADVDERIEAAAQRLKDFPNSGRPGRIEGTRELVIARTPYVAPYQIIGDTVRI
LRVIHGARMWPHDIPPDFGLE

Download         Length: 306 bp

>T156630 NZ_CP069068:1982290-1982538 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11428.93 Da        Isoelectric Point: 4.9006

>AT156630 WP_171743277.1 NZ_CP053346:c715454-715149 [Sphingomonas sp. AP4-R1]
MANNALIQTRIDSDVKDRASAVFERMGLTVSDAVRILLTRTAREGVAPMELLVERQAYDQWFRARVQEALDDDRPDIDDT
EVAARFAELRANARKGIKPVQ

Download         Length: 306 bp

>AT156630 NZ_CP069068:1982078-1982290 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References