Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-CC2985
Location 3185281..3185912 Replicon chromosome
Accession NZ_CP053344
Organism Herbiconiux sp. SALV-R1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HL652_RS15230 Protein ID WP_171707386.1
Coordinates 3185562..3185912 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HL652_RS15225 Protein ID WP_171706093.1
Coordinates 3185281..3185538 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL652_RS15200 3182031..3182231 + 201 WP_171706089.1 hypothetical protein -
HL652_RS15205 3182273..3182626 - 354 WP_171706090.1 ATP-dependent DNA ligase -
HL652_RS15210 3182802..3183878 + 1077 WP_171707385.1 AI-2E family transporter -
HL652_RS15215 3184034..3184579 + 546 WP_171706091.1 DNA starvation/stationary phase protection protein -
HL652_RS15220 3184633..3185139 - 507 WP_171706092.1 PaaI family thioesterase -
HL652_RS15225 3185281..3185538 + 258 WP_171706093.1 ribbon-helix-helix domain-containing protein Antitoxin
HL652_RS15230 3185562..3185912 + 351 WP_171707386.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HL652_RS15235 3186027..3187496 - 1470 WP_171706094.1 PLP-dependent aminotransferase family protein -
HL652_RS15240 3187559..3188137 + 579 Protein_2999 hypothetical protein -
HL652_RS15245 3188245..3188835 - 591 WP_171706095.1 Fe-S cluster assembly protein HesB -
HL652_RS15250 3188832..3189662 - 831 WP_171706096.1 hydrolase -
HL652_RS15255 3189673..3190344 - 672 WP_171706097.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-116)

Antitoxin

Antitoxin ParD

(5-66)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12142.92 Da        Isoelectric Point: 8.9991

>T156629 WP_171707386.1 NZ_CP053344:3185562-3185912 [Herbiconiux sp. SALV-R1]
MLRRGQIVIVALDPVVGSEASKTRPAVVVSNNAANQSAARTGRGVVAVVPVTSNTSRVFPFQVLLPASATGLSLDSKAQP
EQLRSVSVERVGESVGWVPSELMGEVDDAIRLHLGL

Download         Length: 351 bp

>T156629 NZ_CP069068:c1961792-1961403 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8846.52 Da        Isoelectric Point: 3.9248

>AT156629 WP_171706093.1 NZ_CP053344:3185281-3185538 [Herbiconiux sp. SALV-R1]
VSAHKISLSLQESDLAFLDGETLEGRYPSRSAVVQDAIRVLRESRLADAYAEAFGEWDDSGDAALWESTAADGLESAGGS
GTGAA

Download         Length: 258 bp

>AT156629 NZ_CP069068:c1962016-1961789 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References