Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1675050..1675681 Replicon chromosome
Accession NZ_CP053344
Organism Herbiconiux sp. SALV-R1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HL652_RS08090 Protein ID WP_171704862.1
Coordinates 1675050..1675463 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HL652_RS08095 Protein ID WP_171704863.1
Coordinates 1675460..1675681 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL652_RS08055 1670221..1670451 - 231 WP_171704855.1 hypothetical protein -
HL652_RS08060 1670488..1671183 - 696 WP_171704856.1 Trp biosynthesis-associated membrane protein -
HL652_RS08065 1671183..1672718 - 1536 WP_171704857.1 anthranilate synthase component I -
HL652_RS08070 1672723..1673079 - 357 WP_171704858.1 phosphoribosyl-AMP cyclohydrolase -
HL652_RS08075 1673076..1673846 - 771 WP_171704859.1 imidazole glycerol phosphate synthase subunit HisF -
HL652_RS08080 1673846..1674685 - 840 WP_171704860.1 ATP phosphoribosyltransferase -
HL652_RS08085 1674747..1675010 - 264 WP_171704861.1 phosphoribosyl-ATP diphosphatase -
HL652_RS08090 1675050..1675463 - 414 WP_171704862.1 PIN domain nuclease Toxin
HL652_RS08095 1675460..1675681 - 222 WP_171704863.1 antitoxin Antitoxin
HL652_RS08100 1675748..1677235 - 1488 WP_171704864.1 rRNA small subunit methyltransferase B -
HL652_RS08105 1677232..1678146 - 915 WP_171704865.1 methionyl-tRNA formyltransferase -
HL652_RS08110 1678143..1680143 - 2001 WP_171707244.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14814.95 Da        Isoelectric Point: 4.7396

>T156627 WP_171704862.1 NZ_CP053344:c1675463-1675050 [Herbiconiux sp. SALV-R1]
MTEWLIDKSALARLSVSEDPALWAERIERGLVHICVVTRLELGYSARSGADFASIFQLPPVSSLIVANLTPAIEERAHQV
QGFLADRGLHRSASLADLLIAATAEASRLTVLHLDKDFDLIAGLTGQEVERLALADG

Download         Length: 414 bp

>T156627 NZ_CP069068:1694612-1694929 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCTAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8218.31 Da        Isoelectric Point: 4.2666

>AT156627 WP_171704863.1 NZ_CP053344:c1675681-1675460 [Herbiconiux sp. SALV-R1]
MSDLLIRDVPDDVVADIDAQAAVLGLSRAEYVRRQLISEARRVKSTVTVDDLVRSEKLFSGLLDDDLMNDAWR

Download         Length: 222 bp

>AT156627 NZ_CP069068:1694313-1694615 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGATGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References