Detailed information of TA system TA156625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 545407..545960
• Replicon: chromosome
• Accession: NZ_CP053344
• Organism: Herbiconiux sp. SALV-R1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HL652_RS02695
• Protein ID: WP_171703869.1
• Coordinates: 545688..545960 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HL652_RS02690
• Protein ID: WP_171703868.1
• Coordinates: 545407..545691 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HL652_RS02665	540825..541877	-	1053	WP_171703863.1	iron-siderophore ABC transporter substrate-binding protein	-
HL652_RS02670	542007..542801	+	795	WP_171703864.1	AraC family transcriptional regulator	-
HL652_RS02675	542890..543756	-	867	WP_171703865.1	Fpg/Nei family DNA glycosylase	-
HL652_RS02680	543826..544311	-	486	WP_171703866.1	MarR family winged helix-turn-helix transcriptional regulator	-
HL652_RS02685	544386..545363	+	978	WP_171703867.1	zinc-binding dehydrogenase	-
HL652_RS02690	545407..545691	+	285	WP_171703868.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HL652_RS02695	545688..545960	+	273	WP_171703869.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HL652_RS02700	545990..546784	+	795	WP_171703870.1	SDR family oxidoreductase	-
HL652_RS02705	546808..547923	-	1116	WP_171703871.1	serine hydrolase	-
HL652_RS02710	548074..549531	+	1458	WP_171703872.1	amino acid permease	-
HL652_RS02715	549579..550922	+	1344	WP_171707145.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10397.10 Da
• Isoelectric Point: 10.1925

>T156625 WP_171703869.1 NZ_CP053344:545688-545960 [Herbiconiux sp. SALV-R1]
MSHVYDVRFTRSAKKALAEDLPEKVATAAFEFIMGALRSNPKRVGKQLEEPLFPLYSARRGEYRVLYRVLDAQVIIEVVT
IVHRRDAYKT

Nucleotide

• Length: 273 bp

>T156625 NZ_CP069068:1547448-1548269 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9836.05 Da
• Isoelectric Point: 4.2457

>AT156625 WP_171703868.1 NZ_CP053344:545407-545691 [Herbiconiux sp. SALV-R1]
MATLSVADARANFSKLVESASKTHERFEVTRNGSRAAVLLSADDYDTMVETIEILSDAATVEAIRVGLAEIGAGDVVDVG
DVRAAMIEAGRIPG

Nucleotide

• Length: 285 bp

>AT156625 NZ_CP069068:1548262-1548498 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG