Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3517621..3518281 Replicon chromosome
Accession NZ_CP053336
Organism Salmonella bongori serovar 48:z81:- strain 08-0158

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag HLD05_RS16510 Protein ID WP_000244759.1
Coordinates 3517868..3518281 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag HLD05_RS16505 Protein ID WP_000351186.1
Coordinates 3517621..3517887 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLD05_RS16485 3513618..3515051 - 1434 WP_020845166.1 6-phospho-beta-glucosidase -
HLD05_RS16490 3515209..3515520 + 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
HLD05_RS16495 3515684..3516343 + 660 WP_024143399.1 hemolysin III family protein -
HLD05_RS16500 3516394..3517374 - 981 WP_000896119.1 tRNA-modifying protein YgfZ -
HLD05_RS16505 3517621..3517887 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
HLD05_RS16510 3517868..3518281 + 414 WP_000244759.1 protein YgfX Toxin
HLD05_RS16515 3518333..3518854 - 522 WP_001055887.1 flavodoxin FldB -
HLD05_RS16520 3518967..3519863 + 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
HLD05_RS16525 3519887..3520600 + 714 WP_020845161.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HLD05_RS16530 3520606..3522339 + 1734 WP_020845160.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T156624 WP_000244759.1 NZ_CP053336:3517868-3518281 [Salmonella bongori serovar 48:z81:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T156624 NZ_CP069068:c1393938-1393645 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT156624 WP_000351186.1 NZ_CP053336:3517621-3517887 [Salmonella bongori serovar 48:z81:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT156624 NZ_CP069068:c1394204-1393935 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References