Detailed information of TA system TA156623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 2095864..2096507
• Replicon: chromosome
• Accession: NZ_CP053336
• Organism: Salmonella bongori serovar 48:z81:- strain 08-0158

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: S5NG96
• Locus tag: HLD05_RS09875
• Protein ID: WP_020845936.1
• Coordinates: 2096091..2096507 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: HLD05_RS09870
• Protein ID: WP_079779144.1
• Coordinates: 2095864..2096094 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLD05_RS09855	2090876..2092528	+	1653	WP_020845939.1	alpha,alpha-phosphotrehalase	-
HLD05_RS09860	2092935..2095073	+	2139	WP_000187812.1	anaerobic ribonucleoside-triphosphate reductase	-
HLD05_RS09865	2095233..2095697	+	465	WP_001199276.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HLD05_RS09870	2095864..2096094	+	231	WP_079779144.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HLD05_RS09875	2096091..2096507	+	417	WP_020845936.1	type II toxin-antitoxin system VapC family toxin	Toxin
HLD05_RS09880	2096568..2098481	-	1914	WP_020845935.1	BglG family transcription antiterminator	-
HLD05_RS09885	2098498..2099238	-	741	WP_000779268.1	KDGP aldolase family protein	-
HLD05_RS09890	2099235..2100353	-	1119	WP_020845934.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
HLD05_RS09895	2100337..2101470	-	1134	WP_020845933.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-47)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15253.58 Da
• Isoelectric Point: 7.1895

>T156623 WP_020845936.1 NZ_CP053336:2096091-2096507 [Salmonella bongori serovar 48:z81:-]
MSKTYMLDTCICSFIMREQPEAVLKRLEQTVLRCHRIVVSAITYAEMRFGWTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPDLQYEDWVK

Nucleotide

• Length: 417 bp

>T156623 NZ_CP069068:1389493-1389924 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8891.94 Da
• Isoelectric Point: 4.8483

>AT156623 WP_079779144.1 NZ_CP053336:2095864-2096094 [Salmonella bongori serovar 48:z81:-]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPVRPSWGSFRHEEKASPDFLTEREDIVSNEGRFEL

Nucleotide

• Length: 231 bp

>AT156623 NZ_CP069068:1389236-1389496 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: S5NG96