Detailed information of TA system TA156621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 418113..418855
• Replicon: chromosome
• Accession: NZ_CP053336
• Organism: Salmonella bongori serovar 48:z81:- strain 08-0158

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: S5N833
• Locus tag: HLD05_RS01950
• Protein ID: WP_020844237.1
• Coordinates: 418367..418855 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: HLD05_RS01945
• Protein ID: WP_020844238.1
• Coordinates: 418113..418379 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLD05_RS01935	413352..415880	+	2529	WP_020844240.1	malto-oligosyltrehalose synthase	-
HLD05_RS01940	415923..417998	+	2076	WP_020844239.1	glycogen debranching protein GlgX	-
HLD05_RS01945	418113..418379	+	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
HLD05_RS01950	418367..418855	+	489	WP_020844237.1	GNAT family N-acetyltransferase	Toxin
HLD05_RS01955	419378..419767	+	390	WP_015702869.1	RidA family protein	-
HLD05_RS01960	419835..420914	-	1080	WP_020844235.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
HLD05_RS01965	421091..421579	-	489	WP_020844234.1	MarR family winged helix-turn-helix transcriptional regulator	-
HLD05_RS01970	421624..423131	+	1508	Protein_389	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17749.50 Da
• Isoelectric Point: 9.5852

>T156621 WP_020844237.1 NZ_CP053336:418367-418855 [Salmonella bongori serovar 48:z81:-]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T156621 NZ_CP069068:c1234827-1234516 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT156621 WP_020844238.1 NZ_CP053336:418113-418379 [Salmonella bongori serovar 48:z81:-]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT156621 NZ_CP069068:c1235147-1234827 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Structures

Toxin

• AlphaFold DB: S5N833

Antitoxin

• AlphaFold DB: S5MPV7