Detailed information of TA system TA156609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1819237..1819876
• Replicon: chromosome
• Accession: NZ_CP053301
• Organism: Burkholderia cenocepacia strain K56-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K562_RS25435
• Protein ID: WP_006481544.1
• Coordinates: 1819237..1819653 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: K562_RS25440
• Protein ID: WP_006481537.1
• Coordinates: 1819640..1819876 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K562_RS25410	1814344..1815444	-	1101	WP_006481534.1	nitronate monooxygenase	-
K562_RS25415	1815441..1816361	-	921	WP_006481536.1	enoyl-CoA hydratase	-
K562_RS25420	1816370..1817167	-	798	WP_006481539.1	hypothetical protein	-
K562_RS25425	1817178..1818071	-	894	WP_006481548.1	CoA transferase subunit A	-
K562_RS25430	1818081..1818977	-	897	WP_006481531.1	VOC family protein	-
K562_RS25435	1819237..1819653	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
K562_RS25440	1819640..1819876	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
K562_RS25445	1820369..1821595	+	1227	WP_006481535.1	acyltransferase	-
K562_RS25450	1821606..1822283	-	678	WP_077176171.1	hypothetical protein	-
K562_RS25455	1822932..1823705	-	774	WP_006481545.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T156609 WP_006481544.1 NZ_CP053301:c1819653-1819237 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T156609 NZ_CP069068:c699550-699137 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGATACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT156609 WP_006481537.1 NZ_CP053301:c1819876-1819640 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT156609 NZ_CP069068:c699783-699547 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554