Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PHD-RelE
Location 2217131..2217651 Replicon chromosome
Accession NZ_CP053291
Organism Trueperella sp. 19M2397

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HLG82_RS10100 Protein ID WP_193326695.1
Coordinates 2217131..2217391 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HLG82_RS10105 Protein ID WP_193326696.1
Coordinates 2217388..2217651 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG82_RS10085 2212990..2213694 + 705 WP_193326693.1 TrkA family potassium uptake protein -
HLG82_RS10090 2213816..2214436 + 621 WP_193326694.1 TetR/AcrR family transcriptional regulator -
HLG82_RS10095 2214433..2217126 + 2694 WP_193327816.1 DEAD/DEAH box helicase -
HLG82_RS10100 2217131..2217391 - 261 WP_193326695.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLG82_RS10105 2217388..2217651 - 264 WP_193326696.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLG82_RS10110 2217747..2219015 + 1269 WP_193326697.1 methyltransferase domain-containing protein -
HLG82_RS10115 2219098..2219622 - 525 WP_193326698.1 lipocalin family protein -
HLG82_RS10120 2219621..2219851 + 231 WP_193326699.1 hypothetical protein -
HLG82_RS10125 2219875..2221626 + 1752 WP_193326700.1 putative DNA binding domain-containing protein -
HLG82_RS10130 2221923..2222624 - 702 WP_193326701.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(7-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9957.48 Da        Isoelectric Point: 10.5719

>T156577 WP_193326695.1 NZ_CP053291:c2217391-2217131 [Trueperella sp. 19M2397]
VSYRVELTTAAARQIKKLPHEARGRILDALEKLADDPRPRGAKKLVGEQNAWRIRLGDYRIIYDIFDDILTATIVRAGHR
REIYRS

Download         Length: 261 bp

>T156577 NZ_CP069067:c2252896-2252552 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9524.68 Da        Isoelectric Point: 4.6412

>AT156577 WP_193326696.1 NZ_CP053291:c2217651-2217388 [Trueperella sp. 19M2397]
MNTITSEVSTRELRSQLSDVLGRAMYAGERIGVTRHGKLAAVVVSVADLEALEEFEMAQDVAAYRAARAEDDGGRVSLDE
LRRTLTQ

Download         Length: 264 bp

>AT156577 NZ_CP069067:c2253138-2252890 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References