Detailed information of TA system TA156576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2106171..2106781
• Replicon: chromosome
• Accession: NZ_CP053291
• Organism: Trueperella sp. 19M2397

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HLG82_RS09600
• Protein ID: WP_193326609.1
• Coordinates: 2106171..2106542 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HLG82_RS09605
• Protein ID: WP_193326610.1
• Coordinates: 2106539..2106781 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG82_RS09575	2101400..2102236	+	837	WP_193327807.1	sugar ABC transporter permease	-
HLG82_RS09580	2102239..2103084	+	846	WP_193326605.1	carbohydrate ABC transporter permease	-
HLG82_RS09585	2103254..2104582	+	1329	WP_193326606.1	sugar ABC transporter substrate-binding protein	-
HLG82_RS09590	2104737..2105525	+	789	WP_193326607.1	hypothetical protein	-
HLG82_RS09595	2105552..2106124	-	573	WP_193326608.1	low molecular weight phosphotyrosine protein phosphatase	-
HLG82_RS09600	2106171..2106542	-	372	WP_193326609.1	type II toxin-antitoxin system VapC family toxin	Toxin
HLG82_RS09605	2106539..2106781	-	243	WP_193326610.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HLG82_RS09610	2106931..2108202	+	1272	WP_193326611.1	dicarboxylate/amino acid:cation symporter	-
HLG82_RS09615	2108378..2109343	-	966	WP_193326612.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
HLG82_RS09620	2109500..2110831	+	1332	WP_193326613.1	DUF1624 domain-containing protein	-
HLG82_RS09625	2110831..2111385	+	555	WP_193326614.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-119)

Antitoxin

• Antitoxin VapB-like (4-79)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13351.28 Da
• Isoelectric Point: 4.6533

>T156576 WP_193326609.1 NZ_CP053291:c2106542-2106171 [Trueperella sp. 19M2397]
MIVDTSALVAVAYREPGYERITDLLFARNRSKMSVASVLELQLVLRSSELADELIEIFNVDPVGIDVAQLRVARHAAQRF
GKGTGSKAGLNYGDCFSYALAMTAGEPLLFVGEDFTHTDVVVA

Nucleotide

• Length: 372 bp

>T156576 NZ_CP069067:c2251544-2250984 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9044.19 Da
• Isoelectric Point: 5.1599

>AT156576 WP_193326610.1 NZ_CP053291:c2106781-2106539 [Trueperella sp. 19M2397]
MPTMNIKDADVYNAARQLAQLRGTSMTGAVRSAVEEALDAEIKRRERGRLRLAELQDRIAQAAEPRLDESDLYDDRGMPR

Nucleotide

• Length: 243 bp

>AT156576 NZ_CP069067:c2251882-2251541 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA