Detailed information of TA system TA156572

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4571707..4572506
• Replicon: chromosome
• Accession: NZ_CP053286
• Organism: Serratia marcescens strain FZSF02

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HMI62_RS22045
• Protein ID: WP_171404398.1
• Coordinates: 4572129..4572506 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HMI62_RS22040
• Protein ID: WP_171404397.1
• Coordinates: 4571707..4572072 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMI62_RS22005	4567103..4568131	+	1029	WP_171402891.1	IS21 family transposase	-
HMI62_RS22010	4568128..4568919	+	792	WP_171402890.1	IS21-like element helper ATPase IstB	-
HMI62_RS22015	4568977..4569309	+	333	Protein_4292	hypothetical protein	-
HMI62_RS22020	4569398..4570216	+	819	WP_171404393.1	DUF945 domain-containing protein	-
HMI62_RS22025	4570487..4570960	+	474	WP_171404394.1	antirestriction protein	-
HMI62_RS22030	4570972..4571451	+	480	WP_171404395.1	DNA repair protein RadC	-
HMI62_RS22035	4571463..4571684	+	222	WP_171404396.1	DUF987 domain-containing protein	-
HMI62_RS22040	4571707..4572072	+	366	WP_171404397.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HMI62_RS22045	4572129..4572506	+	378	WP_171404398.1	TA system toxin CbtA family protein	Toxin
HMI62_RS22050	4572503..4572994	+	492	WP_050861738.1	hypothetical protein	-
HMI62_RS22055	4573024..4573155	+	132	WP_171404399.1	DUF957 domain-containing protein	-
HMI62_RS22060	4573309..4574151	+	843	WP_171404766.1	DUF4942 domain-containing protein	-
HMI62_RS22065	4575891..4577186	+	1296	WP_171404400.1	lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4529520..4578121	48601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13934.09 Da
• Isoelectric Point: 8.7237

>T156572 WP_171404398.1 NZ_CP053286:4572129-4572506 [Serratia marcescens]
MQTLYALPVRKASSRLSPVEIWQQLLTYLLERHYGLSLNDTQFCNDCVIQQHIDAGISLADALNFLVEKSELVRIDRPGF
SIQHQSPFISAIDILRARKAIGLMQRTGYKAVTCAISGRSSGGLQ

Nucleotide

• Length: 378 bp

>T156572 NZ_CP069067:c2214667-2214338 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13384.32 Da
• Isoelectric Point: 6.8411

>AT156572 WP_171404397.1 NZ_CP053286:4571707-4572072 [Serratia marcescens]
MKNTTPVANHDIAEPWWGLKPTVTPCLGARLVQEGNRLHYLADRASIAGTFNNEDLRHLDQAFPVLMKQLELMLVSGELN
PRNQHCVTLYAKGLTCDADTLGSCGYLYIAIYPTSGNSIPR

Nucleotide

• Length: 366 bp

>AT156572 NZ_CP069067:c2215041-2214664 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA