Detailed information of TA system TA156571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4537649..4538184
• Replicon: chromosome
• Accession: NZ_CP053286
• Organism: Serratia marcescens strain FZSF02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D5X8
• Locus tag: HMI62_RS21830
• Protein ID: WP_004929861.1
• Coordinates: 4537649..4537936 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LES3
• Locus tag: HMI62_RS21835
• Protein ID: WP_038883487.1
• Coordinates: 4537933..4538184 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMI62_RS21810	4532974..4533534	+	561	WP_171404765.1	recombinase family protein	-
HMI62_RS21815	4533518..4535179	+	1662	WP_171404375.1	DDE-type integrase/transposase/recombinase	-
HMI62_RS21820	4535112..4536134	+	1023	WP_171404376.1	ExeA family protein	-
HMI62_RS21825	4536290..4536757	-	468	WP_171404377.1	hypothetical protein	-
HMI62_RS21830	4537649..4537936	-	288	WP_004929861.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMI62_RS21835	4537933..4538184	-	252	WP_038883487.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HMI62_RS21840	4538280..4538720	-	441	WP_171404378.1	dehydrogenase	-
HMI62_RS21845	4539326..4540090	-	765	WP_171404379.1	plasmid SOS inhibition protein A	-
HMI62_RS21850	4540087..4540551	-	465	WP_171404380.1	conjugation system SOS inhibitor PsiB	-
HMI62_RS21855	4540594..4542639	-	2046	WP_171404381.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4529520..4578121	48601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10875.93 Da
• Isoelectric Point: 10.2278

>T156571 WP_004929861.1 NZ_CP053286:c4537936-4537649 [Serratia marcescens]
MTYTVKFRESALKEWGKLDKALQQQFAKKLKKCCENPHIPSAKLRGMPGCYKIKLRASGFRLVYEVIDDCLIIAVVAVGK
RERGDVYQLASERLK

Nucleotide

• Length: 288 bp

>T156571 NZ_CP069067:1979749-1979997 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9182.46 Da
• Isoelectric Point: 4.0338

>AT156571 WP_038883487.1 NZ_CP053286:c4538184-4537933 [Serratia marcescens]
MPNIILSDTSASISELKKNPMETVGAGAGFPVAILNRNKPEFYCVPAALYEQMLDALDDQELVRLVNERRSEALVDIDLD
QFA

Nucleotide

• Length: 252 bp

>AT156571 NZ_CP069067:1979537-1979749 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D5X8