Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4483339..4483811 Replicon chromosome
Accession NZ_CP053286
Organism Serratia marcescens strain FZSF02

Toxin (Protein)


Gene name relE Uniprot ID A0A6M5I1I9
Locus tag HMI62_RS21575 Protein ID WP_004937524.1
Coordinates 4483339..4483614 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6M5IFE1
Locus tag HMI62_RS21580 Protein ID WP_004937521.1
Coordinates 4483620..4483811 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI62_RS21550 4478658..4479938 - 1281 WP_015379029.1 polysaccharide deacetylase family protein -
HMI62_RS21555 4480116..4480886 - 771 WP_004937535.1 ABC transporter permease -
HMI62_RS21560 4480883..4481806 - 924 WP_015379030.1 ABC transporter ATP-binding protein -
HMI62_RS21565 4482017..4482673 + 657 WP_016930066.1 carbonate dehydratase -
HMI62_RS21570 4482712..4483248 - 537 WP_048234659.1 hypoxanthine phosphoribosyltransferase -
HMI62_RS21575 4483339..4483614 - 276 WP_004937524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMI62_RS21580 4483620..4483811 - 192 WP_004937521.1 hypothetical protein Antitoxin
HMI62_RS21585 4483917..4485584 - 1668 WP_171404355.1 multicopper oxidase CueO -
HMI62_RS21590 4485802..4486149 + 348 WP_004937515.1 YacC family pilotin-like protein -
HMI62_RS21595 4486275..4487138 + 864 WP_171404356.1 polyamine aminopropyltransferase -
HMI62_RS21600 4487166..4487960 + 795 WP_171404357.1 adenosylmethionine decarboxylase -
HMI62_RS21605 4487993..4488355 - 363 WP_004937507.1 protein YacL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10378.14 Da        Isoelectric Point: 6.8785

>T156570 WP_004937524.1 NZ_CP053286:c4483614-4483339 [Serratia marcescens]
MLIVKWTDEAKTGLYTLLAFIAERNPVAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VGVLHARQEYP

Download         Length: 276 bp

>T156570 NZ_CP069067:c1959251-1958862 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7188.98 Da        Isoelectric Point: 5.6492

>AT156570 WP_004937521.1 NZ_CP053286:c4483811-4483620 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDTPRVPHDEVMAGARHIIEQAKAKRKSA

Download         Length: 192 bp

>AT156570 NZ_CP069067:c1959475-1959248 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5I1I9

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5IFE1

References