Detailed information of TA system TA156569

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4370442..4371111
• Replicon: chromosome
• Accession: NZ_CP053286
• Organism: Serratia marcescens strain FZSF02

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HMI62_RS21045
• Protein ID: WP_171404321.1
• Coordinates: 4370442..4370864 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: HMI62_RS21050
• Protein ID: WP_019455657.1
• Coordinates: 4370845..4371111 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMI62_RS21025	4366369..4368102	-	1734	WP_171404320.1	single-stranded-DNA-specific exonuclease RecJ	-
HMI62_RS21030	4368109..4368825	-	717	WP_042785306.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HMI62_RS21035	4368852..4369751	-	900	WP_033644935.1	site-specific tyrosine recombinase XerD	-
HMI62_RS21040	4369858..4370376	+	519	WP_033635825.1	flavodoxin FldB	-
HMI62_RS21045	4370442..4370864	-	423	WP_171404321.1	protein YgfX	Toxin
HMI62_RS21050	4370845..4371111	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
HMI62_RS21055	4371432..4372424	+	993	WP_171404322.1	tRNA-modifying protein YgfZ	-
HMI62_RS21060	4372463..4372960	-	498	WP_171404323.1	DUF2165 domain-containing protein	-
HMI62_RS21065	4373111..4373785	-	675	WP_021505704.1	hemolysin III family protein	-
HMI62_RS21070	4373969..4374577	+	609	WP_004931670.1	HD domain-containing protein	-
HMI62_RS21075	4374618..4375544	-	927	WP_015378971.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16469.56 Da
• Isoelectric Point: 11.0198

>T156569 WP_171404321.1 NZ_CP053286:c4370864-4370442 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQG

Nucleotide

• Length: 423 bp

>T156569 NZ_CP069067:1775360-1775764 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT156569 WP_019455657.1 NZ_CP053286:c4371111-4370845 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT156569 NZ_CP069067:1775151-1775354 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04