Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1117515..1118136 Replicon chromosome
Accession NZ_CP053286
Organism Serratia marcescens strain FZSF02

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HMI62_RS05255 Protein ID WP_004940313.1
Coordinates 1117515..1117718 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HMI62_RS05260 Protein ID WP_004940312.1
Coordinates 1117768..1118136 (-) Length 123 a.a.

Genomic Context


HMI62_RS05225HMI62_RS05230HMI62_RS05240HMI62_RS05270HMI62_RS05275HMI62_RS05280HMI62_RS05235HMI62_RS05245HMI62_RS05255HMI62_RS05260HMI62_RS05265HMI62_RS05285HMI62_RS05290
Location: 1113212..1113550 (339 bp)
Type: Others
Protein ID: WP_004940327.1
Location: 1113587..1114873 (1287 bp)
Type: Others
Protein ID: WP_004940322.1
Location: 1116059..1116550 (492 bp)
Type: Others
Protein ID: WP_015376855.1
Location: 1119050..1119763 (714 bp)
Type: Others
Protein ID: WP_171403083.1
Location: 1119760..1120617 (858 bp)
Type: Others
Protein ID: WP_044031827.1
Location: 1120643..1121521 (879 bp)
Type: Others
Protein ID: WP_171403084.1
Location: 1114964..1115827 (864 bp)
Type: Others
Protein ID: WP_015376854.1
Location: 1116615..1116929 (315 bp)
Type: Others
Protein ID: WP_015376856.1
Location: 1117515..1117718 (204 bp)
Type: Toxin
Protein ID: WP_004940313.1
Location: 1117768..1118136 (369 bp)
Type: Antitoxin
Protein ID: WP_004940312.1
Location: 1118295..1118648 (354 bp)
Type: Others
Protein ID: WP_004940311.1
Location: 1121629..1121769 (141 bp)
Type: Others
Protein ID: WP_004940304.1
Location: 1121782..1122036 (255 bp)
Type: Others
Protein ID: WP_004940303.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMI62_RS052251113212..1113550+339WP_004940327.1P-II family nitrogen regulator-
HMI62_RS052301113587..1114873+1287WP_004940322.1ammonium transporter AmtB-
HMI62_RS052351114964..1115827-864WP_015376854.1acyl-CoA thioesterase II-
HMI62_RS052401116059..1116550+492WP_015376855.1YbaY family lipoprotein-
HMI62_RS052451116615..1116929-315WP_015376856.1MGMT family protein-
HMI62_RS052551117515..1117718-204WP_004940313.1hemolysin expression modulator HhaToxin
HMI62_RS052601117768..1118136-369WP_004940312.1Hha toxicity modulator TomBAntitoxin
HMI62_RS052651118295..1118648-354WP_004940311.1hypothetical protein-
HMI62_RS052701119050..1119763+714WP_171403083.1ABC transporter ATP-binding protein-
HMI62_RS052751119760..1120617+858WP_044031827.1metal ABC transporter permease-
HMI62_RS052801120643..1121521+879WP_171403084.1metal ABC transporter substrate-binding protein-
HMI62_RS052851121629..1121769-141WP_004940304.1type B 50S ribosomal protein L36-
HMI62_RS052901121782..1122036-255WP_004940303.1type B 50S ribosomal protein L31-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T156557 WP_004940313.1 NZ_CP053286:c1117718-1117515 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T156557 NZ_CP069067:c759767-759330 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT156557 WP_004940312.1 NZ_CP053286:c1118136-1117768 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT156557 NZ_CP069067:c759220-758975 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4G7F9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2X2G5J9

References