Detailed information of TA system TA156556

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 551086..551789
• Replicon: chromosome
• Accession: NZ_CP053286
• Organism: Serratia marcescens strain FZSF02

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HMI62_RS02545
• Protein ID: WP_171402893.1
• Coordinates: 551448..551789 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HMI62_RS02540
• Protein ID: WP_171404662.1
• Coordinates: 551086..551412 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMI62_RS02505	546649..547122	+	474	WP_171402888.1	hypothetical protein	-
HMI62_RS02510	547148..547606	+	459	WP_171402889.1	hypothetical protein	-
HMI62_RS02515	547703..548200	+	498	Protein_475	DUF945 domain-containing protein	-
HMI62_RS02520	548246..549037	-	792	WP_171402890.1	IS21-like element helper ATPase IstB	-
HMI62_RS02525	549034..550062	-	1029	WP_171402891.1	IS21 family transposase	-
HMI62_RS02530	550150..550497	+	348	Protein_478	DUF932 domain-containing protein	-
HMI62_RS02535	550568..551041	+	474	WP_171402892.1	DNA repair protein RadC	-
HMI62_RS02540	551086..551412	+	327	WP_171404662.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HMI62_RS02545	551448..551789	+	342	WP_171402893.1	TA system toxin CbtA family protein	Toxin
HMI62_RS02550	551904..552737	+	834	WP_171402894.1	DUF4942 domain-containing protein	-
HMI62_RS02555	552814..553062	+	249	WP_171404663.1	ribbon-helix-helix domain-containing protein	-
HMI62_RS02560	553066..553341	+	276	WP_086530362.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HMI62_RS02565	553458..554255	+	798	WP_171402895.1	helix-turn-helix transcriptional regulator	-
HMI62_RS02570	554841..555959	-	1119	WP_049300784.1	HNH endonuclease	-
HMI62_RS02575	556189..556497	-	309	WP_049300783.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	531557..558131	26574
	-	flank	IS/Tn	-	-	548246..549037	791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12916.83 Da
• Isoelectric Point: 8.5195

>T156556 WP_171402893.1 NZ_CP053286:551448-551789 [Serratia marcescens]
MKTLPASTQRAAKPCPTPVVVWQTLLTRLLEQHYGLTLNDTPFCDETVIQEHINAGITLADAVNFLVEKYELIRIDRRGF
SWQEQSPYLRAVDILRARQATGLLRQSHNLSTR

Nucleotide

• Length: 342 bp

>T156556 NZ_CP069067:c758988-758680 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12360.00 Da
• Isoelectric Point: 5.5564

>AT156556 WP_171404662.1 NZ_CP053286:551086-551412 [Serratia marcescens]
MEKNDPIEWGLRRDITPRVGARLVQEGNQLHYLVDRAGVTGIFNEAESRKLNAAFPHFVEQMELILLSGELNPRYAHCVT
LYHDGFTCEADTLGSYGYVYIVIYPTQR

Nucleotide

• Length: 327 bp

>AT156556 NZ_CP069067:c759220-758975 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA