Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 495019..495590 Replicon chromosome
Accession NZ_CP053286
Organism Serratia marcescens strain FZSF02

Toxin (Protein)


Gene name relE Uniprot ID A0A6M5HME0
Locus tag HMI62_RS02300 Protein ID WP_061799809.1
Coordinates 495315..495590 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag HMI62_RS02295 Protein ID WP_013811307.1
Coordinates 495019..495306 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI62_RS02270 490788..491873 - 1086 WP_049243059.1 carbon-phosphorus lyase complex subunit PhnI -
HMI62_RS02275 491873..492454 - 582 WP_171402862.1 phosphonate C-P lyase system protein PhnH -
HMI62_RS02280 492458..492901 - 444 WP_016929298.1 phosphonate C-P lyase system protein PhnG -
HMI62_RS02285 492902..493630 - 729 WP_015376439.1 phosphonate metabolism transcriptional regulator PhnF -
HMI62_RS02290 493858..494913 + 1056 WP_044029843.1 permease -
HMI62_RS02295 495019..495306 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HMI62_RS02300 495315..495590 + 276 WP_061799809.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HMI62_RS02305 495596..496060 - 465 WP_171402863.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HMI62_RS02310 496229..498367 - 2139 WP_049294746.1 anaerobic ribonucleoside-triphosphate reductase -
HMI62_RS02315 498612..499526 - 915 WP_171402864.1 LysR family transcriptional regulator -
HMI62_RS02320 499632..500156 + 525 WP_033641685.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10766.50 Da        Isoelectric Point: 8.4940

>T156555 WP_061799809.1 NZ_CP053286:495315-495590 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAEQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T156555 NZ_CP069067:c757362-756979 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT156555 WP_013811307.1 NZ_CP053286:495019-495306 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT156555 NZ_CP069067:c757612-757457 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5HME0

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References