Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 91575..92340 Replicon chromosome
Accession NZ_CP053286
Organism Serratia marcescens strain FZSF02

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HMI62_RS00405 Protein ID WP_171402743.1
Coordinates 91972..92340 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HMI62_RS00400 Protein ID WP_171402742.1
Coordinates 91575..91913 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI62_RS00370 86708..87010 + 303 WP_080353210.1 hypothetical protein -
HMI62_RS00375 87023..87334 + 312 WP_171402738.1 hypothetical protein -
HMI62_RS00380 87953..89113 + 1161 WP_171402739.1 putative lipopolysaccharide heptosyltransferase III -
HMI62_RS00385 89165..90400 + 1236 WP_171402740.1 O-antigen ligase family protein -
HMI62_RS00390 90581..91039 + 459 WP_171402741.1 antirestriction protein -
HMI62_RS00395 91064..91546 + 483 WP_152692871.1 DNA repair protein RadC -
HMI62_RS00400 91575..91913 + 339 WP_171402742.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HMI62_RS00405 91972..92340 + 369 WP_171402743.1 TA system toxin CbtA family protein Toxin
HMI62_RS00410 92337..92666 + 330 WP_171402744.1 hypothetical protein -
HMI62_RS00415 92767..93600 + 834 WP_171402745.1 DUF4942 domain-containing protein -
HMI62_RS00420 93688..94731 + 1044 WP_171402746.1 virulence RhuM family protein -
HMI62_RS00425 94945..95457 + 513 WP_171402747.1 DUF962 domain-containing protein -
HMI62_RS00430 95459..96199 + 741 WP_171402748.1 nucleotidyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13413.42 Da        Isoelectric Point: 8.5167

>T156554 WP_171402743.1 NZ_CP053286:91972-92340 [Serratia marcescens]
MRTVPAPPSRAAQTCPSSITVWQSLLTYLLAQHYGLTLNDTTFSEDAVIQAHIDDGISLADALNAMVEKFELVRIDRRGF
TGQAQSPLVTVIDILRARRACGLMTRAGYREVTRAIQGVKQP

Download         Length: 369 bp

>T156554 NZ_CP069067:721745-722152 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12634.28 Da        Isoelectric Point: 6.5921

>AT156554 WP_171402742.1 NZ_CP053286:91575-91913 [Serratia marcescens]
MPSPHNVPAWGLKRNVTPQFGARLVQEGERLHFLADRADICGAFSNAQRHDLDNAFPQFINHLELMLLSGELNPRHQHCV
TLYCHGLTCEADSLGSYGYVYISIYPTPETPR

Download         Length: 339 bp

>AT156554 NZ_CP069067:721488-721748 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References