Detailed information of TA system TA156553

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5211402..5212236
• Replicon: chromosome
• Accession: NZ_CP053284
• Organism: Escherichia coli strain SCU-104

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HHJ22_RS25225
• Protein ID: WP_001518317.1
• Coordinates: 5211402..5211779 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ22_RS25230
• Protein ID: WP_024187829.1
• Coordinates: 5211868..5212236 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ22_RS25195	5206767..5207690	-	924	WP_000535961.1	carboxylate/amino acid/amine transporter	-
HHJ22_RS25200	5207801..5208985	-	1185	WP_001172876.1	sugar efflux transporter	-
HHJ22_RS25205	5209367..5209513	-	147	WP_001315909.1	hypothetical protein	-
HHJ22_RS25210	5209778..5210623	-	846	WP_001518322.1	DUF4942 domain-containing protein	-
HHJ22_RS25215	5210708..5210905	-	198	WP_000839251.1	DUF957 domain-containing protein	-
HHJ22_RS25220	5210917..5211405	-	489	WP_032330753.1	hypothetical protein	-
HHJ22_RS25225	5211402..5211779	-	378	WP_001518317.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HHJ22_RS25230	5211868..5212236	-	369	WP_024187829.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
HHJ22_RS25235	5212315..5212536	-	222	WP_000692312.1	DUF987 domain-containing protein	-
HHJ22_RS25240	5212605..5213081	-	477	WP_001518017.1	RadC family protein	-
HHJ22_RS25245	5213097..5213570	-	474	WP_032330754.1	antirestriction protein	-
HHJ22_RS25250	5213664..5213909	-	246	WP_001518015.1	hypothetical protein	-
HHJ22_RS25255	5213909..5214730	-	822	WP_032330755.1	DUF945 domain-containing protein	-
HHJ22_RS25260	5214831..5215040	-	210	Protein_4932	DUF905 family protein	-
HHJ22_RS25265	5215141..5215596	-	456	WP_033804098.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13964.02 Da
• Isoelectric Point: 8.9341

>T156553 WP_001518317.1 NZ_CP053284:c5211779-5211402 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKYPEAKR

Nucleotide

• Length: 378 bp

>T156553 NZ_CP069067:720127-720522 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13631.41 Da
• Isoelectric Point: 6.2044

>AT156553 WP_024187829.1 NZ_CP053284:c5212236-5211868 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT156553 NZ_CP069067:719873-720127 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA