Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4490899..4491731 Replicon chromosome
Accession NZ_CP053284
Organism Escherichia coli strain SCU-104

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag HHJ22_RS21835 Protein ID WP_000854753.1
Coordinates 4490899..4491273 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HHJ22_RS21840 Protein ID WP_001278232.1
Coordinates 4491363..4491731 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ22_RS21805 4486114..4487220 + 1107 WP_001315214.1 N-acetylneuraminate epimerase -
HHJ22_RS21810 4487285..4488265 + 981 WP_001295601.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HHJ22_RS21815 4488273..4488923 - 651 WP_001037966.1 HNH endonuclease -
HHJ22_RS21820 4489968..4490120 - 153 WP_001280445.1 hypothetical protein -
HHJ22_RS21825 4490205..4490402 - 198 WP_000839281.1 DUF957 domain-containing protein -
HHJ22_RS21830 4490414..4490902 - 489 WP_000777547.1 hypothetical protein -
HHJ22_RS21835 4490899..4491273 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
HHJ22_RS21840 4491363..4491731 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HHJ22_RS21845 4491894..4492115 - 222 WP_000692345.1 DUF987 domain-containing protein -
HHJ22_RS21850 4492202..4492678 - 477 WP_001186781.1 RadC family protein -
HHJ22_RS21855 4492694..4493179 - 486 WP_151329467.1 antirestriction protein -
HHJ22_RS21860 4493234..4494055 - 822 WP_098733456.1 DUF945 domain-containing protein -
HHJ22_RS21865 4494156..4494365 - 210 Protein_4285 DUF905 family protein -
HHJ22_RS21870 4494466..4494921 - 456 WP_033804098.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T156551 WP_000854753.1 NZ_CP053284:c4491273-4490899 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T156551 NZ_CP069067:706948-707349 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT156551 WP_001278232.1 NZ_CP053284:c4491731-4491363 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT156551 NZ_CP069067:706706-706951 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References