156511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3694040..3694877 Replicon chromosome
Accession NZ_CP053281
Organism Escherichia coli strain SCU-308

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag HHJ45_RS17895 Protein ID WP_000227784.1
Coordinates 3694335..3694877 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag HHJ45_RS17890 Protein ID WP_001297137.1
Coordinates 3694040..3694351 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ45_RS17865 3689060..3690007 + 948 WP_021548571.1 cytochrome o ubiquinol oxidase subunit II -
HHJ45_RS17870 3690029..3692020 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HHJ45_RS17875 3692010..3692624 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HHJ45_RS17880 3692624..3692953 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HHJ45_RS17885 3692965..3693855 + 891 WP_000971336.1 heme o synthase -
HHJ45_RS17890 3694040..3694351 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
HHJ45_RS17895 3694335..3694877 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
HHJ45_RS17900 3694933..3695868 - 936 WP_001297127.1 sel1 repeat family protein -
HHJ45_RS17905 3696276..3697640 + 1365 WP_001000978.1 MFS transporter -
HHJ45_RS17910 3697768..3698259 - 492 WP_001138904.1 nucleotide binding protein YajQ -
HHJ45_RS17915 3698427..3699338 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T156511 WP_000227784.1 NZ_CP053281:3694335-3694877 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T156511 NZ_CP069066:1770873-1771277 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT156511 WP_001297137.1 NZ_CP053281:3694040-3694351 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT156511 NZ_CP069066:1770664-1770867 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References