156458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1747688..1748306 Replicon chromosome
Accession NZ_CP053258
Organism Escherichia coli strain GF4-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HLY11_RS08310 Protein ID WP_001291435.1
Coordinates 1748088..1748306 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HLY11_RS08305 Protein ID WP_000344800.1
Coordinates 1747688..1748062 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLY11_RS08295 1742777..1743970 + 1194 WP_112027666.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HLY11_RS08300 1743993..1747142 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HLY11_RS08305 1747688..1748062 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HLY11_RS08310 1748088..1748306 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HLY11_RS08315 1748478..1749029 + 552 WP_171459716.1 maltose O-acetyltransferase -
HLY11_RS08320 1749145..1749615 + 471 WP_001490888.1 YlaC family protein -
HLY11_RS08325 1749779..1751329 + 1551 WP_171459717.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HLY11_RS08330 1751371..1751724 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HLY11_RS08340 1752103..1752414 + 312 WP_000409911.1 MGMT family protein -
HLY11_RS08345 1752445..1753017 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T156458 WP_001291435.1 NZ_CP053258:1748088-1748306 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T156458 NZ_CP069065:c2191780-2191451 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT156458 WP_000344800.1 NZ_CP053258:1747688-1748062 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT156458 NZ_CP069065:c2192154-2191777 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References