Detailed information of TA system TA156456

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1036532..1037364
• Replicon: chromosome
• Accession: NZ_CP053258
• Organism: Escherichia coli strain GF4-3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HLY11_RS05070
• Protein ID: WP_052953490.1
• Coordinates: 1036532..1036906 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HLY11_RS05075
• Protein ID: WP_024210831.1
• Coordinates: 1036996..1037364 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLY11_RS05035	1031821..1032312	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
HLY11_RS05040	1032414..1032968	-	555	WP_001001902.1	molecular chaperone YcdY	-
HLY11_RS05045	1032992..1033729	-	738	WP_000283664.1	zinc-binding phosphatase	-
HLY11_RS05050	1033784..1034722	-	939	WP_171459512.1	glyoxylate/hydroxypyruvate reductase GhrA	-
HLY11_RS05060	1035193..1036035	-	843	WP_005020348.1	DUF4942 domain-containing protein	-
HLY11_RS05065	1036080..1036535	-	456	WP_149003091.1	hypothetical protein	-
HLY11_RS05070	1036532..1036906	-	375	WP_052953490.1	TA system toxin CbtA family protein	Toxin
HLY11_RS05075	1036996..1037364	-	369	WP_024210831.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HLY11_RS05080	1037444..1037666	-	223	Protein_1001	DUF987 domain-containing protein	-
HLY11_RS05085	1037729..1038205	-	477	WP_001383023.1	RadC family protein	-
HLY11_RS05090	1038221..1038700	-	480	WP_001383022.1	antirestriction protein	-
HLY11_RS05095	1038794..1039039	-	246	WP_052953489.1	hypothetical protein	-
HLY11_RS05100	1039039..1039857	-	819	WP_052953488.1	DUF945 domain-containing protein	-
HLY11_RS05105	1039947..1040885	-	939	WP_000060628.1	hypothetical protein	-
HLY11_RS05110	1040951..1041361	-	411	WP_000642912.1	hypothetical protein	-
HLY11_RS05115	1041467..1041682	-	216	WP_052953487.1	hypothetical protein	-
HLY11_RS05120	1041695..1041841	-	147	WP_001383016.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	csgB / csgD / csgE / csgF / csgG	1028203..1067000	38797

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14012.12 Da
• Isoelectric Point: 8.7236

>T156456 WP_052953490.1 NZ_CP053258:c1036906-1036532 [Escherichia coli]
MKTLPDTYVREASRCPSPVTIWQILLGRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCVAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPQAK

Nucleotide

• Length: 375 bp

>T156456 NZ_CP069065:c1936094-1935705 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13635.42 Da
• Isoelectric Point: 7.3992

>AT156456 WP_024210831.1 NZ_CP053258:c1037364-1036996 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQESNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSRGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT156456 NZ_CP069065:c1936318-1936091 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA