Detailed information of TA system TA156402

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3080465..3081266
• Replicon: chromosome
• Accession: NZ_CP053247
• Organism: Escherichia coli strain SCU-482

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: U9ZA48
• Locus tag: HHJ51_RS15000
• Protein ID: WP_001513431.1
• Coordinates: 3080465..3080842 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: U9YYT7
• Locus tag: HHJ51_RS15005
• Protein ID: WP_001513429.1
• Coordinates: 3080889..3081266 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ51_RS14975	3076597..3077580	-	984	WP_001329577.1	KpsF/GutQ family sugar-phosphate isomerase	-
HHJ51_RS14980	3078390..3078560	-	171	Protein_2920	IS110 family transposase	-
HHJ51_RS14985	3078903..3079745	-	843	WP_001513432.1	DUF4942 domain-containing protein	-
HHJ51_RS14990	3079830..3080027	-	198	WP_001374283.1	DUF957 domain-containing protein	-
HHJ51_RS14995	3080039..3080468	-	430	Protein_2923	hypothetical protein	-
HHJ51_RS15000	3080465..3080842	-	378	WP_001513431.1	TA system toxin CbtA family protein	Toxin
HHJ51_RS15005	3080889..3081266	-	378	WP_001513429.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ51_RS15010	3081429..3081650	-	222	WP_000692345.1	DUF987 domain-containing protein	-
HHJ51_RS15015	3081713..3082189	-	477	WP_001547087.1	RadC family protein	-
HHJ51_RS15020	3082205..3082690	-	486	WP_001513428.1	antirestriction protein	-
HHJ51_RS15025	3082745..3083563	-	819	WP_001513427.1	DUF945 domain-containing protein	-
HHJ51_RS15030	3083664..3083873	-	210	Protein_2930	DUF905 family protein	-
HHJ51_RS15035	3083974..3084429	-	456	WP_000581502.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13941.80 Da
• Isoelectric Point: 7.3225

>T156402 WP_001513431.1 NZ_CP053247:c3080842-3080465 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T156402 NZ_CP069064:c2199996-2199667 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13688.48 Da
• Isoelectric Point: 5.9505

>AT156402 WP_001513429.1 NZ_CP053247:c3081266-3080889 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Nucleotide

• Length: 378 bp

>AT156402 NZ_CP069064:c2200370-2199993 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: U9ZA48

Antitoxin

• AlphaFold DB: U9YYT7