Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 4772098..4772569 | Replicon | chromosome |
| Accession | NZ_CP053234 | ||
| Organism | Escherichia coli strain SCU-106 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | HHJ24_RS23110 | Protein ID | WP_001303511.1 |
| Coordinates | 4772098..4772376 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | HHJ24_RS23115 | Protein ID | WP_001302048.1 |
| Coordinates | 4772378..4772569 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHJ24_RS23075 | 4767433..4767702 | - | 270 | WP_000003742.1 | excisionase | - |
| HHJ24_RS23080 | 4767764..4770235 | - | 2472 | WP_062883708.1 | exonuclease | - |
| HHJ24_RS23085 | 4770329..4770520 | - | 192 | WP_024218353.1 | lysis protein YdfD | - |
| HHJ24_RS23090 | 4770517..4770705 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| HHJ24_RS23095 | 4771105..4771269 | + | 165 | WP_001299931.1 | hypothetical protein | - |
| HHJ24_RS23100 | 4771273..4771491 | - | 219 | WP_001171952.1 | hypothetical protein | - |
| HHJ24_RS23105 | 4771651..4771806 | - | 156 | WP_000379588.1 | DUF1391 family protein | - |
| HHJ24_RS23110 | 4772098..4772376 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HHJ24_RS23115 | 4772378..4772569 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| HHJ24_RS23120 | 4772590..4772961 | - | 372 | WP_123007420.1 | hypothetical protein | - |
| HHJ24_RS23125 | 4773059..4773361 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| HHJ24_RS23130 | 4773358..4773783 | + | 426 | WP_032210757.1 | Rha family transcriptional regulator | - |
| HHJ24_RS23135 | 4773806..4774768 | + | 963 | WP_016234248.1 | helix-turn-helix domain-containing protein | - |
| HHJ24_RS23140 | 4774775..4775521 | + | 747 | WP_000788950.1 | ATP-binding protein | - |
| HHJ24_RS23145 | 4775543..4776256 | + | 714 | WP_170969545.1 | DUF1627 domain-containing protein | - |
| HHJ24_RS23150 | 4776272..4776663 | + | 392 | Protein_4510 | DUF977 family protein | - |
| HHJ24_RS23155 | 4776690..4777010 | + | 321 | WP_101896892.1 | hypothetical protein | - |
| HHJ24_RS23160 | 4777007..4777231 | + | 225 | WP_021577603.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4766346..4816413 | 50067 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T156346 WP_001303511.1 NZ_CP053234:c4772376-4772098 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T156346 NZ_CP069063:c2198103-2197774 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT156346 WP_001302048.1 NZ_CP053234:c4772569-4772378 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT156346 NZ_CP069063:c2198477-2198100 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|