Detailed information of TA system TA156341

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3523786..3524618
• Replicon: chromosome
• Accession: NZ_CP053234
• Organism: Escherichia coli strain SCU-106

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HHJ24_RS17115
• Protein ID: WP_000854816.1
• Coordinates: 3523786..3524160 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ24_RS17120
• Protein ID: WP_001285402.1
• Coordinates: 3524250..3524618 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ24_RS17085	3519183..3520160	+	978	WP_000633239.1	type II secretion system minor pseudopilin GspK	-
HHJ24_RS17090	3520157..3521335	+	1179	WP_000094989.1	type II secretion system protein GspL	-
HHJ24_RS17095	3521337..3521873	+	537	WP_000942795.1	GspM family type II secretion system protein YghD	-
HHJ24_RS17100	3522154..3522996	-	843	WP_001274564.1	DUF4942 domain-containing protein	-
HHJ24_RS17105	3523081..3523278	-	198	WP_000772027.1	DUF957 domain-containing protein	-
HHJ24_RS17110	3523298..3523789	-	492	WP_000976865.1	hypothetical protein	-
HHJ24_RS17115	3523786..3524160	-	375	WP_000854816.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HHJ24_RS17120	3524250..3524618	-	369	WP_001285402.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ24_RS17125	3524781..3525002	-	222	WP_000692323.1	DUF987 domain-containing protein	-
HHJ24_RS17130	3525071..3525547	-	477	WP_001186727.1	RadC family protein	-
HHJ24_RS17135	3525563..3526042	-	480	WP_000706981.1	antirestriction protein	-
HHJ24_RS17140	3526305..3527123	-	819	WP_001234638.1	DUF945 domain-containing protein	-
HHJ24_RS17145	3527214..3527447	-	234	Protein_3341	DUF905 family protein	-
HHJ24_RS17150	3527522..3527977	-	456	WP_024226900.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14045.05 Da
• Isoelectric Point: 9.1493

>T156341 WP_000854816.1 NZ_CP053234:c3524160-3523786 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Nucleotide

• Length: 375 bp

>T156341 NZ_CP069063:c1577957-1577556 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13883.62 Da
• Isoelectric Point: 6.3165

>AT156341 WP_001285402.1 NZ_CP053234:c3524618-3524250 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELILTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT156341 NZ_CP069063:c1578211-1577954 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA