Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3004215..3004846 Replicon chromosome
Accession NZ_CP053234
Organism Escherichia coli strain SCU-106

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag HHJ24_RS14500 Protein ID WP_001259388.1
Coordinates 3004215..3004490 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HHJ24_RS14505 Protein ID WP_000593555.1
Coordinates 3004487..3004846 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ24_RS14485 2999219..3000286 + 1068 WP_000361485.1 HlyD family secretion protein -
HHJ24_RS14490 3000283..3003018 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
HHJ24_RS14495 3003018..3004142 + 1125 WP_001314210.1 ABC transporter permease -
HHJ24_RS14500 3004215..3004490 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ24_RS14505 3004487..3004846 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ24_RS14510 3004896..3005756 - 861 WP_021554581.1 class II aldolase -
HHJ24_RS14515 3005788..3006057 - 270 WP_021554580.1 HPr family phosphocarrier protein -
HHJ24_RS14520 3006047..3007555 - 1509 WP_021554579.1 xylulose kinase -
HHJ24_RS14525 3007548..3008906 - 1359 WP_170969443.1 PTS galactitol transporter subunit IIC -
HHJ24_RS14530 3008983..3009264 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
HHJ24_RS14535 3009261..3009734 - 474 WP_021554578.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2996616..3004846 8230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T156339 WP_001259388.1 NZ_CP053234:3004215-3004490 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T156339 NZ_CP069063:c1389418-1389125 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCCTC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT156339 WP_000593555.1 NZ_CP053234:3004487-3004846 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT156339 NZ_CP069063:c1389684-1389415 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References