156315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 23496..24021 Replicon plasmid pSCU-306-1
Accession NZ_CP053232
Organism Escherichia coli strain SCU-306

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag HHJ44_RS24365 Protein ID WP_001159871.1
Coordinates 23716..24021 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag HHJ44_RS24360 Protein ID WP_000813630.1
Coordinates 23496..23714 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ44_RS24325 18868..20254 - 1387 Protein_20 hypothetical protein -
HHJ44_RS24330 20382..20569 - 188 Protein_21 hypothetical protein -
HHJ44_RS24335 20781..21207 + 427 Protein_22 hypothetical protein -
HHJ44_RS24340 21225..21572 - 348 WP_001554926.1 hypothetical protein -
HHJ44_RS24345 21683..22030 + 348 WP_021573051.1 hypothetical protein -
HHJ44_RS24350 22048..22644 - 597 WP_001554928.1 hypothetical protein -
HHJ44_RS24355 22632..22901 - 270 WP_001554929.1 hypothetical protein -
HHJ44_RS24360 23496..23714 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HHJ44_RS24365 23716..24021 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
HHJ44_RS24370 24022..24828 + 807 WP_000016968.1 site-specific integrase -
HHJ44_RS24375 25508..26209 - 702 WP_016238649.1 replication initiation protein -
HHJ44_RS24380 26860..28065 + 1206 WP_001442122.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 senB 1..128584 128584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T156315 WP_001159871.1 NZ_CP053232:23716-24021 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T156315 NZ_CP069062:3832388-3832798 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT156315 WP_000813630.1 NZ_CP053232:23496-23714 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT156315 NZ_CP069062:3832113-3832391 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References