Detailed information of TA system TA156306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4053010..4053830
• Replicon: chromosome
• Accession: NZ_CP053231
• Organism: Escherichia coli strain SCU-306

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: HHJ44_RS19535
• Protein ID: WP_001054379.1
• Coordinates: 4053573..4053830 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ44_RS19530
• Protein ID: WP_000123957.1
• Coordinates: 4053010..4053561 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ44_RS19505	4048704..4050017	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
HHJ44_RS19510	4050029..4050307	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ44_RS19515	4050304..4051425	-	1122	WP_000010833.1	M42 family metallopeptidase	-
HHJ44_RS19520	4051824..4052084	-	261	WP_000077645.1	hypothetical protein	-
HHJ44_RS19525	4052212..4052958	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
HHJ44_RS19530	4053010..4053561	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
HHJ44_RS19535	4053573..4053830	-	258	WP_001054379.1	YjhX family toxin	Toxin
HHJ44_RS19540	4054207..4054506	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
HHJ44_RS19545	4054584..4055810	+	1227	Protein_3821	DNA helicase	-
HHJ44_RS19550	4056393..4057373	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HHJ44_RS19555	4057437..4058543	-	1107	WP_001332032.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T156306 WP_001054379.1 NZ_CP053231:c4053830-4053573 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T156306 NZ_CP069062:c3108000-3107644 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT156306 WP_000123957.1 NZ_CP053231:c4053561-4053010 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT156306 NZ_CP069062:c3108214-3107984 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Structures

Toxin

• AlphaFold DB: B6I030