Detailed information of TA system TA156283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 2882465..2883075
• Replicon: chromosome
• Accession: NZ_CP053222
• Organism: Sphingobium sp. RSMS

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: EGM87_RS13925
• Protein ID: WP_137710086.1
• Coordinates: 2882785..2883075 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: EGM87_RS13920
• Protein ID: WP_137710087.1
• Coordinates: 2882465..2882752 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGM87_RS13895	2877506..2877964	-	459	WP_137710092.1	DUF2059 domain-containing protein	-
EGM87_RS13905	2879904..2880410	+	507	WP_137710090.1	transposase	-
EGM87_RS13910	2880529..2881740	+	1212	WP_011950834.1	IS256 family transposase	-
EGM87_RS13915	2881850..2882416	+	567	WP_171407198.1	transposase	-
EGM87_RS13920	2882465..2882752	-	288	WP_137710087.1	putative addiction module antidote protein	Antitoxin
EGM87_RS13925	2882785..2883075	-	291	WP_137710086.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGM87_RS13930	2884418..2885281	+	864	WP_103000632.1	OmpA family protein	-
EGM87_RS13935	2885350..2886366	-	1017	WP_137710085.1	NADP-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2834974..2883075	48101

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-94)

Antitoxin

• Uncharacterized protein HI1420 (4-91)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10647.19 Da
• Isoelectric Point: 10.0413

>T156283 WP_137710086.1 NZ_CP053222:c2883075-2882785 [Sphingobium sp. RSMS]
METQQTPAFADWFESLRDRKAKSKIAGRIARIELGLMGDVKSVGDGVSEARIDFGPGYRLYFTRRGEQLIILLVGGDKSS
QQRDIAKAKEMAAQIS

Nucleotide

• Length: 291 bp

>T156283 NZ_CP069062:c1578589-1578188 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10271.94 Da
• Isoelectric Point: 5.6939

>AT156283 WP_137710087.1 NZ_CP053222:c2882752-2882465 [Sphingobium sp. RSMS]
MAIKLTRFDAAEYLTEPEDQAELLADALTTGDVHVIAKAIGIVARAHGMTELSKETGIKRQQLYRALGPDGNPTLETMLK
VLPALGLRMRIEAAA

Nucleotide

• Length: 288 bp

>AT156283 NZ_CP069062:c1578843-1578586 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA