Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 2453281..2453858 | Replicon | chromosome |
| Accession | NZ_CP053222 | ||
| Organism | Sphingobium sp. RSMS | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A494VYC8 |
| Locus tag | EGM87_RS11790 | Protein ID | WP_066699765.1 |
| Coordinates | 2453281..2453616 (-) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | D4Z5D8 |
| Locus tag | EGM87_RS11795 | Protein ID | WP_013041112.1 |
| Coordinates | 2453616..2453858 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGM87_RS11760 | 2449281..2449427 | - | 147 | WP_171010074.1 | hypothetical protein | - |
| EGM87_RS11765 | 2449700..2450389 | - | 690 | WP_137710296.1 | pentapeptide repeat-containing protein | - |
| EGM87_RS11770 | 2450483..2451121 | - | 639 | WP_137710295.1 | lytic transglycosylase domain-containing protein | - |
| EGM87_RS11775 | 2451121..2451693 | - | 573 | WP_137710294.1 | S26 family signal peptidase | - |
| EGM87_RS11780 | 2451690..2451947 | - | 258 | WP_137710293.1 | helix-turn-helix domain-containing protein | - |
| EGM87_RS11785 | 2452122..2452442 | - | 321 | WP_066699763.1 | DUF736 domain-containing protein | - |
| EGM87_RS11790 | 2453281..2453616 | - | 336 | WP_066699765.1 | endoribonuclease MazF | Toxin |
| EGM87_RS11795 | 2453616..2453858 | - | 243 | WP_013041112.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| EGM87_RS11800 | 2453983..2454204 | - | 222 | WP_137710292.1 | hypothetical protein | - |
| EGM87_RS11805 | 2454372..2456246 | - | 1875 | WP_137710291.1 | ParB N-terminal domain-containing protein | - |
| EGM87_RS11810 | 2456363..2456764 | - | 402 | WP_137710290.1 | DUF2958 domain-containing protein | - |
| EGM87_RS11815 | 2456761..2457819 | - | 1059 | WP_137710289.1 | DUF1738 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2395875..2472672 | 76797 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12025.02 Da Isoelectric Point: 9.5826
>T156282 WP_066699765.1 NZ_CP053222:c2453616-2453281 [Sphingobium sp. RSMS]
MASRYIPDTGDIVWLQFDPQAGHEQAGHRPALVLSPAAYNKLRGMMICCPMTSQIKGYPFEVTVSQAPPSIVLSDQIKSL
DWKARGAKKKGSVSTAVIDEVRAKISALLGL
MASRYIPDTGDIVWLQFDPQAGHEQAGHRPALVLSPAAYNKLRGMMICCPMTSQIKGYPFEVTVSQAPPSIVLSDQIKSL
DWKARGAKKKGSVSTAVIDEVRAKISALLGL
Download Length: 336 bp
>T156282 NZ_CP069062:1543836-1544657 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8624.08 Da Isoelectric Point: 4.6653
>AT156282 WP_013041112.1 NZ_CP053222:c2453858-2453616 [Sphingobium sp. RSMS]
MGIQVKKWGNSAAIRIPSAIMAAAALNVGQEVEVRQEGGRLIIEPVLKPVYTLDALLADMKPETFHEIVDFGPPVGNEVL
MGIQVKKWGNSAAIRIPSAIMAAAALNVGQEVEVRQEGGRLIIEPVLKPVYTLDALLADMKPETFHEIVDFGPPVGNEVL
Download Length: 243 bp
>AT156282 NZ_CP069062:1544650-1544886 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A494VYC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A848HW50 |