Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1876026..1876483 Replicon chromosome
Accession NZ_CP053222
Organism Sphingobium sp. RSMS

Toxin (Protein)


Gene name relE Uniprot ID A0A4Q4J3V7
Locus tag EGM87_RS08815 Protein ID WP_044662619.1
Coordinates 1876208..1876483 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A292ZD49
Locus tag EGM87_RS08810 Protein ID WP_044662618.1
Coordinates 1876026..1876208 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGM87_RS08790 1871145..1874057 + 2913 WP_044662615.1 excinuclease ABC subunit UvrA -
EGM87_RS08795 1874133..1875209 + 1077 WP_044662616.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
EGM87_RS08800 1875217..1875777 + 561 WP_083199195.1 hypothetical protein -
EGM87_RS08805 1875755..1875949 + 195 WP_099185664.1 hypothetical protein -
EGM87_RS08810 1876026..1876208 + 183 WP_044662618.1 hypothetical protein Antitoxin
EGM87_RS08815 1876208..1876483 + 276 WP_044662619.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EGM87_RS08820 1876567..1877568 + 1002 WP_044662620.1 hypothetical protein -
EGM87_RS08825 1877739..1877951 + 213 WP_007684722.1 cold-shock protein -
EGM87_RS08830 1878014..1878190 + 177 WP_171010079.1 hypothetical protein -
EGM87_RS08835 1878319..1878537 + 219 WP_025550213.1 hypothetical protein -
EGM87_RS08840 1878708..1879052 + 345 WP_025550214.1 glycine zipper 2TM domain-containing protein -
EGM87_RS08845 1879110..1880042 - 933 WP_044662621.1 FAD-binding protein -
EGM87_RS08850 1880039..1880788 - 750 WP_044663190.1 electron transfer flavoprotein subunit beta/FixA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10438.92 Da        Isoelectric Point: 6.4801

>T156281 WP_044662619.1 NZ_CP053222:1876208-1876483 [Sphingobium sp. RSMS]
MPHVIWRPKALEDADRIIDYISDRNPAAAARLADLFEYAAERLADHPYMHRAGRVPDTREAIVTPNYILVYRAGADVIEI
LAILHTRQQYP

Download         Length: 276 bp

>T156281 NZ_CP069062:c1389949-1389656 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6641.62 Da        Isoelectric Point: 5.7833

>AT156281 WP_044662618.1 NZ_CP053222:1876026-1876208 [Sphingobium sp. RSMS]
MTKLTPIESEFATTEDAEAYDAWFRAKVEAALADPRPGIPHDQVMAKLRAIIEAKKAKQA

Download         Length: 183 bp

>AT156281 NZ_CP069062:c1390215-1389946 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q4J3V7

Antitoxin

Source ID Structure
AlphaFold DB A0A292ZD49

References