Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ParST/RES-Xre |
| Location | 1002421..1003382 | Replicon | chromosome |
| Accession | NZ_CP053222 | ||
| Organism | Sphingobium sp. RSMS | ||
Toxin (Protein)
| Gene name | ParT | Uniprot ID | A0A5B8CC27 |
| Locus tag | EGM87_RS04665 | Protein ID | WP_044662136.1 |
| Coordinates | 1002421..1002906 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | ParS | Uniprot ID | A0A197BZ03 |
| Locus tag | EGM87_RS04670 | Protein ID | WP_044662137.1 |
| Coordinates | 1002903..1003382 (-) | Length | 160 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGM87_RS04635 | 997889..998308 | + | 420 | WP_044662131.1 | hypothetical protein | - |
| EGM87_RS04640 | 998546..998965 | + | 420 | WP_044662132.1 | helix-turn-helix domain-containing protein | - |
| EGM87_RS04645 | 998975..999607 | + | 633 | WP_044662133.1 | GntR family transcriptional regulator | - |
| EGM87_RS04650 | 999731..999865 | + | 135 | WP_137709742.1 | benenodin family lasso peptide | - |
| EGM87_RS04655 | 999931..1000587 | + | 657 | WP_082718614.1 | lasso peptide biosynthesis B2 protein | - |
| EGM87_RS04660 | 1000587..1002344 | + | 1758 | WP_044662135.1 | asparagine synthase C-terminal domain-containing protein | - |
| EGM87_RS04665 | 1002421..1002906 | - | 486 | WP_044662136.1 | RES family NAD+ phosphorylase | Toxin |
| EGM87_RS04670 | 1002903..1003382 | - | 480 | WP_044662137.1 | MbcA/ParS/Xre antitoxin family protein | Antitoxin |
| EGM87_RS04675 | 1003470..1005551 | - | 2082 | WP_044662138.1 | Atxe2 family lasso peptide isopeptidase | - |
| EGM87_RS04680 | 1005551..1008115 | - | 2565 | WP_052628225.1 | TonB-dependent receptor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 969548..1174967 | 205419 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17375.85 Da Isoelectric Point: 7.1664
>T156280 WP_044662136.1 NZ_CP053222:c1002906-1002421 [Sphingobium sp. RSMS]
VTTSFWRIATDARTYEADDLSGAGAKITGGRWNEVGVAIVYAASSRALACLETVVHLNSGGLPLNRYLVEIEVPDEVLAS
AEVATPGNLPVGWDAEPAGRVSISFGSQWAQSQRTALLLVPSVIVPEETNLLINPAHPDAKGIKARKVRKWLYDPRMIRK
A
VTTSFWRIATDARTYEADDLSGAGAKITGGRWNEVGVAIVYAASSRALACLETVVHLNSGGLPLNRYLVEIEVPDEVLAS
AEVATPGNLPVGWDAEPAGRVSISFGSQWAQSQRTALLLVPSVIVPEETNLLINPAHPDAKGIKARKVRKWLYDPRMIRK
A
Download Length: 486 bp
>T156280 NZ_CP053222:c1002906-1002421 [Sphingobium sp. RSMS]
GTGACGACAAGCTTTTGGAGAATCGCAACCGACGCCAGGACCTATGAAGCGGACGACCTGTCAGGCGCCGGCGCCAAGAT
CACCGGGGGCCGGTGGAATGAGGTCGGCGTCGCCATCGTCTATGCGGCGAGCAGCCGGGCACTCGCCTGCCTGGAGACGG
TCGTTCATCTGAACTCGGGTGGGTTGCCGCTCAATCGCTACCTCGTCGAAATCGAGGTGCCGGACGAGGTGCTGGCATCA
GCGGAGGTCGCGACACCCGGCAATCTCCCGGTCGGCTGGGATGCCGAACCGGCGGGACGGGTCAGCATCTCATTCGGATC
GCAATGGGCGCAGAGCCAAAGGACAGCGCTGCTGCTCGTCCCTTCCGTCATTGTGCCAGAGGAGACTAATCTCCTCATCA
ATCCCGCGCACCCCGATGCCAAGGGGATCAAGGCCCGGAAGGTGCGCAAATGGCTCTATGATCCAAGGATGATCCGCAAG
GCGTGA
GTGACGACAAGCTTTTGGAGAATCGCAACCGACGCCAGGACCTATGAAGCGGACGACCTGTCAGGCGCCGGCGCCAAGAT
CACCGGGGGCCGGTGGAATGAGGTCGGCGTCGCCATCGTCTATGCGGCGAGCAGCCGGGCACTCGCCTGCCTGGAGACGG
TCGTTCATCTGAACTCGGGTGGGTTGCCGCTCAATCGCTACCTCGTCGAAATCGAGGTGCCGGACGAGGTGCTGGCATCA
GCGGAGGTCGCGACACCCGGCAATCTCCCGGTCGGCTGGGATGCCGAACCGGCGGGACGGGTCAGCATCTCATTCGGATC
GCAATGGGCGCAGAGCCAAAGGACAGCGCTGCTGCTCGTCCCTTCCGTCATTGTGCCAGAGGAGACTAATCTCCTCATCA
ATCCCGCGCACCCCGATGCCAAGGGGATCAAGGCCCGGAAGGTGCGCAAATGGCTCTATGATCCAAGGATGATCCGCAAG
GCGTGA
Antitoxin
Download Length: 160 a.a. Molecular weight: 17037.46 Da Isoelectric Point: 5.2707
>AT156280 WP_044662137.1 NZ_CP053222:c1003382-1002903 [Sphingobium sp. RSMS]
MSELETGARKAQGKGTPPFAYKALYRASPVDRIGVIKKGVAASDLKRFIAALHVDQKVMFDALNLKTATVNKKAANNQPL
STEDSERVLGLAKLVGQLEDMVEESGETDGFDAPEWLSSWLRQPLPALGGVNPIDLLDTMEGQAVVSRALAQIQSGAFA
MSELETGARKAQGKGTPPFAYKALYRASPVDRIGVIKKGVAASDLKRFIAALHVDQKVMFDALNLKTATVNKKAANNQPL
STEDSERVLGLAKLVGQLEDMVEESGETDGFDAPEWLSSWLRQPLPALGGVNPIDLLDTMEGQAVVSRALAQIQSGAFA
Download Length: 480 bp
>AT156280 NZ_CP053222:c1003382-1002903 [Sphingobium sp. RSMS]
ATGTCCGAACTCGAAACTGGCGCGCGCAAGGCGCAGGGGAAAGGCACGCCCCCCTTTGCCTATAAGGCGCTGTACCGTGC
CTCGCCGGTCGATCGAATCGGCGTCATCAAGAAGGGCGTGGCGGCCAGCGACCTGAAGCGCTTCATCGCCGCCTTGCATG
TGGACCAGAAGGTCATGTTCGACGCGCTCAATCTCAAGACGGCCACGGTGAACAAGAAGGCGGCGAACAACCAGCCGCTC
TCGACGGAAGACAGTGAACGGGTTCTGGGCCTTGCAAAACTGGTCGGCCAGCTCGAAGACATGGTCGAGGAATCGGGCGA
GACGGATGGGTTCGATGCGCCCGAATGGCTCTCGTCCTGGCTGCGTCAGCCTCTCCCGGCGCTGGGAGGCGTCAATCCGA
TCGATCTTCTCGACACGATGGAGGGACAGGCCGTCGTGTCCCGCGCCCTTGCGCAAATCCAGAGCGGCGCCTTTGCGTGA
ATGTCCGAACTCGAAACTGGCGCGCGCAAGGCGCAGGGGAAAGGCACGCCCCCCTTTGCCTATAAGGCGCTGTACCGTGC
CTCGCCGGTCGATCGAATCGGCGTCATCAAGAAGGGCGTGGCGGCCAGCGACCTGAAGCGCTTCATCGCCGCCTTGCATG
TGGACCAGAAGGTCATGTTCGACGCGCTCAATCTCAAGACGGCCACGGTGAACAAGAAGGCGGCGAACAACCAGCCGCTC
TCGACGGAAGACAGTGAACGGGTTCTGGGCCTTGCAAAACTGGTCGGCCAGCTCGAAGACATGGTCGAGGAATCGGGCGA
GACGGATGGGTTCGATGCGCCCGAATGGCTCTCGTCCTGGCTGCGTCAGCCTCTCCCGGCGCTGGGAGGCGTCAATCCGA
TCGATCTTCTCGACACGATGGAGGGACAGGCCGTCGTGTCCCGCGCCCTTGCGCAAATCCAGAGCGGCGCCTTTGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6D0H | |
| PDB | 6D0I |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6D0H | |
| PDB | 6D0I | |
| AlphaFold DB | A0A197BZ03 |