Detailed information of TA system TA156279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 586559..587157
• Replicon: chromosome
• Accession: NZ_CP053222
• Organism: Sphingobium sp. RSMS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EGM87_RS02715
• Protein ID: WP_137709963.1
• Coordinates: 586559..586858 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGM87_RS02720
• Protein ID: WP_137709962.1
• Coordinates: 586855..587157 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGM87_RS02690	582265..582570	+	306	WP_137709968.1	conjugal transfer protein TraD	-
EGM87_RS02695	582593..582826	+	234	WP_137709967.1	conjugal transfer protein TraD	-
EGM87_RS02700	582819..583406	-	588	WP_171010039.1	hypothetical protein	-
EGM87_RS02705	583418..584032	-	615	WP_137709965.1	hypothetical protein	-
EGM87_RS02710	584424..586160	-	1737	WP_137709964.1	ParB/RepB/Spo0J family partition protein	-
EGM87_RS02715	586559..586858	-	300	WP_137709963.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGM87_RS02720	586855..587157	-	303	WP_137709962.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EGM87_RS02725	587666..587875	+	210	WP_137709961.1	AlpA family transcriptional regulator	-
EGM87_RS02730	588239..589315	-	1077	WP_137709960.1	SAVED domain-containing protein	-
EGM87_RS02735	589312..589788	-	477	WP_137709959.1	Mov34/MPN/PAD-1 family protein	-
EGM87_RS02740	589778..591514	-	1737	WP_137709958.1	ThiF family adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-54)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11120.63 Da
• Isoelectric Point: 5.6976

>T156279 WP_137709963.1 NZ_CP053222:c586858-586559 [Sphingobium sp. RSMS]
MKLAWSQHAAADRLAIFTWIAQDDPRAAALVDDRLEDAARRLIDFPESGRPGRVEGTRELVVARTPYVVPYQIVGDTVRL
LRVIHGARMWPQEINDGDG

Nucleotide

• Length: 300 bp

>T156279 NZ_CP069062:1240579-1240953 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11275.87 Da
• Isoelectric Point: 4.6069

>AT156279 WP_137709962.1 NZ_CP053222:c587157-586855 [Sphingobium sp. RSMS]
MAHNALIQTRIDADVKEQAAAVFEKMGLTVSDAVRILLTRTAREGIVPMELLVEKQAYDEWFRARVQEALDDERPDIPDE
EISATFAALREKARKGLPPQ

Nucleotide

• Length: 303 bp

>AT156279 NZ_CP069062:1240385-1240582 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA