Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 586559..587157 Replicon chromosome
Accession NZ_CP053222
Organism Sphingobium sp. RSMS

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EGM87_RS02715 Protein ID WP_137709963.1
Coordinates 586559..586858 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EGM87_RS02720 Protein ID WP_137709962.1
Coordinates 586855..587157 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGM87_RS02690 582265..582570 + 306 WP_137709968.1 conjugal transfer protein TraD -
EGM87_RS02695 582593..582826 + 234 WP_137709967.1 conjugal transfer protein TraD -
EGM87_RS02700 582819..583406 - 588 WP_171010039.1 hypothetical protein -
EGM87_RS02705 583418..584032 - 615 WP_137709965.1 hypothetical protein -
EGM87_RS02710 584424..586160 - 1737 WP_137709964.1 ParB/RepB/Spo0J family partition protein -
EGM87_RS02715 586559..586858 - 300 WP_137709963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGM87_RS02720 586855..587157 - 303 WP_137709962.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EGM87_RS02725 587666..587875 + 210 WP_137709961.1 AlpA family transcriptional regulator -
EGM87_RS02730 588239..589315 - 1077 WP_137709960.1 SAVED domain-containing protein -
EGM87_RS02735 589312..589788 - 477 WP_137709959.1 Mov34/MPN/PAD-1 family protein -
EGM87_RS02740 589778..591514 - 1737 WP_137709958.1 ThiF family adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-54)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11120.63 Da        Isoelectric Point: 5.6976

>T156279 WP_137709963.1 NZ_CP053222:c586858-586559 [Sphingobium sp. RSMS]
MKLAWSQHAAADRLAIFTWIAQDDPRAAALVDDRLEDAARRLIDFPESGRPGRVEGTRELVVARTPYVVPYQIVGDTVRL
LRVIHGARMWPQEINDGDG

Download         Length: 300 bp

>T156279 NZ_CP069062:1240579-1240953 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11275.87 Da        Isoelectric Point: 4.6069

>AT156279 WP_137709962.1 NZ_CP053222:c587157-586855 [Sphingobium sp. RSMS]
MAHNALIQTRIDADVKEQAAAVFEKMGLTVSDAVRILLTRTAREGIVPMELLVEKQAYDEWFRARVQEALDDERPDIPDE
EISATFAALREKARKGLPPQ

Download         Length: 303 bp

>AT156279 NZ_CP069062:1240385-1240582 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References