Detailed information of TA system TA156275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1839630..1841266
• Replicon: chromosome
• Accession: NZ_CP053218
• Organism: Acinetobacter baumannii strain DT01139C

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I8CRD3
• Locus tag: HLG77_RS08985
• Protein ID: WP_000737054.1
• Coordinates: 1839630..1840961 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HLG77_RS08990
• Protein ID: WP_001101311.1
• Coordinates: 1840958..1841266 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG77_RS08960	1834710..1835948	+	1239	WP_086384442.1	TolC family protein	-
HLG77_RS08965	1835941..1837104	+	1164	WP_001044497.1	hypothetical protein	-
HLG77_RS08970	1837232..1838203	+	972	WP_086384441.1	acid phosphatase	-
HLG77_RS08975	1838215..1838859	+	645	WP_000817299.1	hypothetical protein	-
HLG77_RS08980	1838894..1839334	-	441	WP_000193124.1	HD domain-containing protein	-
HLG77_RS08985	1839630..1840961	+	1332	WP_000737054.1	type II toxin-antitoxin system HipA family toxin	Toxin
HLG77_RS08990	1840958..1841266	+	309	WP_001101311.1	helix-turn-helix domain-containing protein	Antitoxin
HLG77_RS08995	1841990..1842538	+	549	WP_025465053.1	TetR/AcrR family transcriptional regulator	-
HLG77_RS09000	1843028..1844827	+	1800	WP_000269398.1	KAP family P-loop domain protein	-
HLG77_RS09005	1844841..1845605	+	765	WP_000537342.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-82)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51171.17 Da
• Isoelectric Point: 4.7950

>T156275 WP_000737054.1 NZ_CP053218:1839630-1840961 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEIPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T156275 NZ_CP069062:845053-845481 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11620.50 Da
• Isoelectric Point: 9.9701

>AT156275 WP_001101311.1 NZ_CP053218:1840958-1841266 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKSNE

Nucleotide

• Length: 309 bp

>AT156275 NZ_CP069062:844772-845029 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I8CRD3