Detailed information of TA system TA156274

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 451922..452563
• Replicon: chromosome
• Accession: NZ_CP053218
• Organism: Acinetobacter baumannii strain DT01139C

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2S4T466
• Locus tag: HLG77_RS02240
• Protein ID: WP_000607071.1
• Coordinates: 452174..452563 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HLG77_RS02235
• Protein ID: WP_171059649.1
• Coordinates: 451922..452167 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG77_RS02215	447426..448433	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HLG77_RS02220	448452..448829	+	378	WP_001216380.1	50S ribosomal protein L17	-
HLG77_RS02225	449011..450501	+	1491	WP_179993676.1	NAD(P)/FAD-dependent oxidoreductase	-
HLG77_RS02230	450550..451722	-	1173	WP_002058246.1	acyl-CoA dehydrogenase family protein	-
HLG77_RS02235	451922..452167	+	246	WP_171059649.1	succinate dehydrogenase assembly factor 2	Antitoxin
HLG77_RS02240	452174..452563	+	390	WP_000607071.1	membrane protein	Toxin
HLG77_RS02245	453333..454418	+	1086	WP_000049106.1	hypothetical protein	-
HLG77_RS02250	454496..455062	+	567	WP_000651536.1	rhombosortase	-
HLG77_RS02255	455250..455846	+	597	WP_002058236.1	hypothetical protein	-
HLG77_RS02260	455972..456181	-	210	WP_000745523.1	YheV family putative metal-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15649.98 Da
• Isoelectric Point: 10.4623

>T156274 WP_000607071.1 NZ_CP053218:452174-452563 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T156274 NZ_CP069062:c759174-758737 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9856.29 Da
• Isoelectric Point: 4.9108

>AT156274 WP_171059649.1 NZ_CP053218:451922-452167 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT156274 NZ_CP069062:c759425-759171 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Structures

Toxin

• AlphaFold DB: A0A2S4T466