Detailed information of TA system TA156272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2797492..2798171
• Replicon: chromosome
• Accession: NZ_CP053215
• Organism: Acinetobacter baumannii strain DT0544C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HLG75_RS13520
• Protein ID: WP_000838146.1
• Coordinates: 2797989..2798171 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HLG75_RS13515
• Protein ID: WP_000966688.1
• Coordinates: 2797492..2797896 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG75_RS13505	2792511..2796812	-	4302	WP_179994555.1	tape measure protein	-
HLG75_RS13510	2796883..2797392	-	510	WP_000734512.1	hypothetical protein	-
HLG75_RS13515	2797492..2797896	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HLG75_RS13520	2797989..2798171	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HLG75_RS13525	2798497..2799012	-	516	WP_001185588.1	hypothetical protein	-
HLG75_RS13530	2799083..2800000	-	918	WP_179994556.1	hypothetical protein	-
HLG75_RS13535	2800053..2801231	-	1179	WP_179994557.1	phage tail protein	-
HLG75_RS13540	2801231..2801584	-	354	WP_115729093.1	hypothetical protein	-
HLG75_RS13545	2801681..2802202	-	522	WP_115729095.1	SH3 domain-containing protein	-
HLG75_RS13550	2802311..2802529	-	219	WP_115729096.1	hypothetical protein	-
HLG75_RS13555	2802531..2802974	-	444	WP_115729098.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2782603..2828239	45636

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T156272 WP_000838146.1 NZ_CP053215:c2798171-2797989 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T156272 NZ_CP069062:c758395-758087 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT156272 WP_000966688.1 NZ_CP053215:c2797896-2797492 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT156272 NZ_CP069062:c758627-758382 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6