Detailed information of TA system TA156271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1849588..1851224
• Replicon: chromosome
• Accession: NZ_CP053215
• Organism: Acinetobacter baumannii strain DT0544C

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: HLG75_RS08870
• Protein ID: WP_000737056.1
• Coordinates: 1849588..1850919 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HLG75_RS08875
• Protein ID: WP_001101308.1
• Coordinates: 1850916..1851224 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG75_RS08845	1844672..1845910	+	1239	WP_011859301.1	TolC family protein	-
HLG75_RS08850	1845903..1847063	+	1161	WP_001044492.1	hypothetical protein	-
HLG75_RS08855	1847190..1848161	+	972	WP_109104914.1	acid phosphatase	-
HLG75_RS08860	1848173..1848817	+	645	WP_000817301.1	hypothetical protein	-
HLG75_RS08865	1848852..1849292	-	441	WP_000193135.1	HD domain-containing protein	-
HLG75_RS08870	1849588..1850919	+	1332	WP_000737056.1	type II toxin-antitoxin system HipA family toxin	Toxin
HLG75_RS08875	1850916..1851224	+	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
HLG75_RS08880	1851950..1852501	+	552	WP_005135235.1	TetR/AcrR family transcriptional regulator	-
HLG75_RS08885	1852717..1853337	+	621	WP_000658761.1	hypothetical protein	-
HLG75_RS08890	1853355..1854437	+	1083	WP_001095788.1	ImmA/IrrE family metallo-endopeptidase	-
HLG75_RS08895	1854479..1854994	+	516	WP_000914805.1	hypothetical protein	-
HLG75_RS08900	1855142..1855660	+	519	WP_000651611.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T156271 WP_000737056.1 NZ_CP053215:1849588-1850919 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T156271 NZ_CP069062:c756769-756386 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT156271 WP_001101308.1 NZ_CP053215:1850916-1851224 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT156271 NZ_CP069062:c757019-756864 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1