Detailed information of TA system TA156270

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1263436..1264115
• Replicon: chromosome
• Accession: NZ_CP053215
• Organism: Acinetobacter baumannii strain DT0544C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HLG75_RS06075
• Protein ID: WP_000838146.1
• Coordinates: 1263436..1263618 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HLG75_RS06080
• Protein ID: WP_000966688.1
• Coordinates: 1263711..1264115 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG75_RS06040	1258925..1259455	+	531	WP_001056874.1	Rha family transcriptional regulator	-
HLG75_RS06045	1259452..1259649	+	198	WP_000858628.1	hypothetical protein	-
HLG75_RS06050	1259716..1259916	+	201	WP_000632855.1	hypothetical protein	-
HLG75_RS06055	1260024..1260377	+	354	WP_000064602.1	hypothetical protein	-
HLG75_RS06060	1260377..1261555	+	1179	WP_179994576.1	phage tail protein	-
HLG75_RS06065	1261608..1262525	+	918	WP_000094278.1	hypothetical protein	-
HLG75_RS06070	1262595..1263110	+	516	WP_179994577.1	hypothetical protein	-
HLG75_RS06075	1263436..1263618	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HLG75_RS06080	1263711..1264115	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HLG75_RS06085	1264214..1264738	+	525	WP_057047896.1	DUF4468 domain-containing protein	-
HLG75_RS06090	1264802..1265725	+	924	WP_000732599.1	hypothetical protein	-
HLG75_RS06095	1265742..1266026	-	285	WP_000085802.1	hypothetical protein	-
HLG75_RS06100	1266168..1267115	+	948	WP_179994578.1	alpha/beta hydrolase	-
HLG75_RS06105	1267235..1267744	+	510	WP_057078075.1	Rha family transcriptional regulator	-
HLG75_RS06110	1267868..1268215	+	348	WP_057078074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	adeH / adeG / adeF	1226925..1290560	63635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T156270 WP_000838146.1 NZ_CP053215:1263436-1263618 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T156270 NZ_CP069062:721152-721559 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT156270 WP_000966688.1 NZ_CP053215:1263711-1264115 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT156270 NZ_CP069062:720895-721155 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6