Detailed information of TA system TA156268

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 465296..465937
• Replicon: chromosome
• Accession: NZ_CP053215
• Organism: Acinetobacter baumannii strain DT0544C

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1E3M967
• Locus tag: HLG75_RS02305
• Protein ID: WP_009518132.1
• Coordinates: 465548..465937 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HLG75_RS02300
• Protein ID: WP_011860336.1
• Coordinates: 465296..465541 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG75_RS02280	460799..461806	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HLG75_RS02285	461825..462202	+	378	WP_001216380.1	50S ribosomal protein L17	-
HLG75_RS02290	462384..463874	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
HLG75_RS02295	463924..465096	-	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
HLG75_RS02300	465296..465541	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HLG75_RS02305	465548..465937	+	390	WP_009518132.1	hypothetical protein	Toxin
HLG75_RS02310	466707..467792	+	1086	WP_000049106.1	hypothetical protein	-
HLG75_RS02315	467871..468437	+	567	WP_000651536.1	rhombosortase	-
HLG75_RS02320	468625..470820	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15720.03 Da
• Isoelectric Point: 10.4623

>T156268 WP_009518132.1 NZ_CP053215:465548-465937 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T156268 NZ_CP069062:713875-714276 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT156268 WP_011860336.1 NZ_CP053215:465296-465541 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT156268 NZ_CP069062:713651-713878 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: A0A1E3M967