Detailed information of TA system TA156247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1770073..1770735
• Replicon: chromosome
• Accession: NZ_CP053210
• Organism: Streptococcus pneumoniae strain 6A-10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HKM25_RS08955
• Protein ID: WP_000192221.1
• Coordinates: 1770562..1770735 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HKM25_RS08950
• Protein ID: WP_000961815.1
• Coordinates: 1770073..1770525 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKM25_RS08925	1765963..1766706	-	744	WP_001188224.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
HKM25_RS08930	1766708..1767658	-	951	WP_000451163.1	50S ribosomal protein L11 methyltransferase	-
HKM25_RS08935	1767796..1768224	-	429	WP_000401989.1	NUDIX hydrolase	-
HKM25_RS08940	1768226..1769293	-	1068	WP_000719718.1	M50 family metallopeptidase	-
HKM25_RS08945	1769312..1769782	-	471	WP_000257089.1	DUF3013 family protein	-
HKM25_RS08950	1770073..1770525	-	453	WP_000961815.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HKM25_RS08955	1770562..1770735	-	174	WP_000192221.1	type II toxin-antitoxin system HicA family toxin	Toxin
HKM25_RS08960	1770878..1771057	-	180	WP_001809903.1	hypothetical protein	-
HKM25_RS08965	1771222..1771461	-	240	WP_000818078.1	hypothetical protein	-
HKM25_RS08970	1771731..1773002	+	1272	WP_001113216.1	replication-associated recombination protein A	-
HKM25_RS08980	1773547..1774866	-	1320	WP_054362602.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6368.47 Da
• Isoelectric Point: 10.8214

>T156247 WP_000192221.1 NZ_CP053210:c1770735-1770562 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 174 bp

>T156247 NZ_CP069046:c4946599-4946315 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16587.39 Da
• Isoelectric Point: 3.7412

>AT156247 WP_000961815.1 NZ_CP053210:c1770525-1770073 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFGYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT156247 NZ_CP069046:c4946831-4946589 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA