Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1770073..1770735 Replicon chromosome
Accession NZ_CP053210
Organism Streptococcus pneumoniae strain 6A-10

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKM25_RS08955 Protein ID WP_000192221.1
Coordinates 1770562..1770735 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKM25_RS08950 Protein ID WP_000961815.1
Coordinates 1770073..1770525 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKM25_RS08925 1765963..1766706 - 744 WP_001188224.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
HKM25_RS08930 1766708..1767658 - 951 WP_000451163.1 50S ribosomal protein L11 methyltransferase -
HKM25_RS08935 1767796..1768224 - 429 WP_000401989.1 NUDIX hydrolase -
HKM25_RS08940 1768226..1769293 - 1068 WP_000719718.1 M50 family metallopeptidase -
HKM25_RS08945 1769312..1769782 - 471 WP_000257089.1 DUF3013 family protein -
HKM25_RS08950 1770073..1770525 - 453 WP_000961815.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKM25_RS08955 1770562..1770735 - 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
HKM25_RS08960 1770878..1771057 - 180 WP_001809903.1 hypothetical protein -
HKM25_RS08965 1771222..1771461 - 240 WP_000818078.1 hypothetical protein -
HKM25_RS08970 1771731..1773002 + 1272 WP_001113216.1 replication-associated recombination protein A -
HKM25_RS08980 1773547..1774866 - 1320 WP_054362602.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T156247 WP_000192221.1 NZ_CP053210:c1770735-1770562 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

>T156247 NZ_CP069046:c4946599-4946315 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16587.39 Da        Isoelectric Point: 3.7412

>AT156247 WP_000961815.1 NZ_CP053210:c1770525-1770073 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFGYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT156247 NZ_CP069046:c4946831-4946589 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References