Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
Location | 975707..976959 | Replicon | chromosome |
Accession | NZ_CP053210 | ||
Organism | Streptococcus pneumoniae strain 6A-10 |
Toxin (Protein)
Gene name | pezT | Uniprot ID | - |
Locus tag | HKM25_RS04985 | Protein ID | WP_000405363.1 |
Coordinates | 976183..976959 (+) | Length | 259 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | B6ZCC4 |
Locus tag | HKM25_RS04980 | Protein ID | WP_000579612.1 |
Coordinates | 975707..976183 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HKM25_RS04950 | 971048..971236 | + | 189 | WP_000179769.1 | hypothetical protein | - |
HKM25_RS04955 | 971298..972056 | + | 759 | WP_000262028.1 | ATP-grasp domain-containing protein | - |
HKM25_RS04960 | 972114..972968 | + | 855 | WP_000900015.1 | ADP-ribosylglycohydrolase family protein | - |
HKM25_RS04965 | 973080..973964 | + | 885 | WP_000710115.1 | diacylglycerol kinase family lipid kinase | - |
HKM25_RS04970 | 974127..974831 | + | 705 | WP_001809570.1 | alpha amylase N-terminal ig-like domain-containing protein | - |
HKM25_RS04975 | 974981..975262 | + | 282 | WP_000266233.1 | hypothetical protein | - |
HKM25_RS04980 | 975707..976183 | + | 477 | WP_000579612.1 | helix-turn-helix domain-containing protein | Antitoxin |
HKM25_RS04985 | 976183..976959 | + | 777 | WP_000405363.1 | zeta toxin family protein | Toxin |
HKM25_RS04990 | 976949..978706 | + | 1758 | WP_000394602.1 | AAA family ATPase | - |
HKM25_RS04995 | 978699..980237 | + | 1539 | WP_001279800.1 | ATP-dependent helicase | - |
HKM25_RS05000 | 981131..981487 | + | 357 | WP_001115086.1 | hypothetical protein | - |
HKM25_RS05005 | 981492..981857 | + | 366 | WP_000431637.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 968213..1003741 | 35528 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 259 a.a. Molecular weight: 29726.77 Da Isoelectric Point: 7.2008
>T156245 WP_000405363.1 NZ_CP053210:976183-976959 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSSVYDLKENTTSAADVLQELLFGEWSQVEKEML
RVVEERHKELEGKNSYGI
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSSVYDLKENTTSAADVLQELLFGEWSQVEKEML
RVVEERHKELEGKNSYGI
Download Length: 777 bp
>T156245 NZ_CP069046:4229320-4229538 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT156245 WP_000579612.1 NZ_CP053210:975707-976183 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT156245 NZ_CP069046:4228919-4229293 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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