156245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 975707..976959 Replicon chromosome
Accession NZ_CP053210
Organism Streptococcus pneumoniae strain 6A-10

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag HKM25_RS04985 Protein ID WP_000405363.1
Coordinates 976183..976959 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag HKM25_RS04980 Protein ID WP_000579612.1
Coordinates 975707..976183 (+) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKM25_RS04950 971048..971236 + 189 WP_000179769.1 hypothetical protein -
HKM25_RS04955 971298..972056 + 759 WP_000262028.1 ATP-grasp domain-containing protein -
HKM25_RS04960 972114..972968 + 855 WP_000900015.1 ADP-ribosylglycohydrolase family protein -
HKM25_RS04965 973080..973964 + 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
HKM25_RS04970 974127..974831 + 705 WP_001809570.1 alpha amylase N-terminal ig-like domain-containing protein -
HKM25_RS04975 974981..975262 + 282 WP_000266233.1 hypothetical protein -
HKM25_RS04980 975707..976183 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
HKM25_RS04985 976183..976959 + 777 WP_000405363.1 zeta toxin family protein Toxin
HKM25_RS04990 976949..978706 + 1758 WP_000394602.1 AAA family ATPase -
HKM25_RS04995 978699..980237 + 1539 WP_001279800.1 ATP-dependent helicase -
HKM25_RS05000 981131..981487 + 357 WP_001115086.1 hypothetical protein -
HKM25_RS05005 981492..981857 + 366 WP_000431637.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 968213..1003741 35528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-213)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 259 a.a.        Molecular weight: 29726.77 Da        Isoelectric Point: 7.2008

>T156245 WP_000405363.1 NZ_CP053210:976183-976959 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSSVYDLKENTTSAADVLQELLFGEWSQVEKEML
RVVEERHKELEGKNSYGI

Download         Length: 777 bp

>T156245 NZ_CP069046:4229320-4229538 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT156245 WP_000579612.1 NZ_CP053210:975707-976183 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT156245 NZ_CP069046:4228919-4229293 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References