Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_26
Location 275404..276006 Replicon chromosome
Accession NZ_CP053205
Organism Rhizobium leguminosarum bv. trifolii TA1

Toxin (Protein)


Gene name relE Uniprot ID A0A4Q8ZZ56
Locus tag RLTA1_RS01405 Protein ID WP_018072489.1
Coordinates 275404..275649 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4Q8ZYY9
Locus tag RLTA1_RS01410 Protein ID WP_018072490.1
Coordinates 275659..276006 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RLTA1_RS01365 270827..271258 + 432 WP_012755989.1 DUF2948 family protein -
RLTA1_RS01370 271375..272673 + 1299 WP_027689562.1 histidinol dehydrogenase -
RLTA1_RS01375 272678..273151 + 474 WP_018072486.1 UPF0262 family protein -
RLTA1_RS01380 273148..273633 + 486 WP_017992883.1 phosphotyrosine protein phosphatase -
RLTA1_RS01385 273757..273975 + 219 WP_003545338.1 translation initiation factor IF-1 -
RLTA1_RS01390 274033..274653 + 621 WP_003545339.1 Maf-like protein -
RLTA1_RS01395 274787..274999 + 213 WP_017990235.1 DNA gyrase inhibitor YacG -
RLTA1_RS01405 275404..275649 + 246 WP_018072489.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
RLTA1_RS01410 275659..276006 + 348 WP_018072490.1 helix-turn-helix transcriptional regulator Antitoxin
RLTA1_RS01415 276292..276570 - 279 WP_003545380.1 transposase -
RLTA1_RS01420 276578..278023 - 1446 WP_027689563.1 HlyD family type I secretion periplasmic adaptor subunit -
RLTA1_RS01425 278038..279753 - 1716 WP_027689564.1 type I secretion system permease/ATPase -
RLTA1_RS01430 279844..280419 - 576 WP_018072494.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(60-114)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 8978.54 Da        Isoelectric Point: 10.6821

>T156239 WP_018072489.1 NZ_CP053205:275404-275649 [Rhizobium leguminosarum bv. trifolii TA1]
MKKIAYSKAAAKALRKMQPKRAAAIVAKVEAFANGETVDLKKLQGSDFFRIRVGQDRVVIDDQTMQVLVIKAGPRGDIYN
E

Download         Length: 246 bp

>T156239 NZ_CP069046:337269-337637 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12533.12 Da        Isoelectric Point: 4.3851

>AT156239 WP_018072490.1 NZ_CP053205:275659-276006 [Rhizobium leguminosarum bv. trifolii TA1]
MGEIQKLTIDGKGYVLLSEDDYQDLVDVSDARAAKARIDAGEETWPEDVVKALIAGEDPVRVFRKHRGMSIKELAKKSGL
SQPYLSEIETGKKEGSLDALRSIASALDVDLDDVA

Download         Length: 348 bp

>AT156239 NZ_CP069046:337051-337272 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q8ZZ56

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q8ZYY9

References