Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 212880..213406 Replicon plasmid pMS-37a
Accession NZ_CP053191
Organism Enterobacter hormaechei strain EGYMCRVIM

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HK406_RS23560 Protein ID WP_000323025.1
Coordinates 212880..213167 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HK406_RS23565 Protein ID WP_126680804.1
Coordinates 213167..213406 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK406_RS23525 208450..208626 - 177 WP_001371930.1 hypothetical protein -
HK406_RS23530 209137..210081 + 945 WP_000778029.1 DUF5417 domain-containing protein -
HK406_RS23535 210180..210779 + 600 WP_001031420.1 hypothetical protein -
HK406_RS23540 210839..211189 + 351 WP_000743059.1 hypothetical protein -
HK406_RS23545 211236..211439 + 204 WP_001015183.1 hypothetical protein -
HK406_RS23550 211721..212041 + 321 WP_000332796.1 hypothetical protein -
HK406_RS23555 212650..212808 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
HK406_RS23560 212880..213167 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HK406_RS23565 213167..213406 - 240 WP_126680804.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HK406_RS23570 213669..214592 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
HK406_RS23575 214792..215364 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HK406_RS23580 215840..217078 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaVIM-1 / aac(6')-Il / dfrA1 / aadA1 / qacE / sul1 / tet(A) / mcr-9 - 1..270915 270915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T156237 WP_000323025.1 NZ_CP053191:c213167-212880 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T156237 NZ_CP069004:128985-129560 [Sulfitobacter mediterraneus]
ATGAGTGACTATGCCGACCGTTTCACGGCACTGATTGACGCAAATGTTCTGGCGTGCGCGATGCGGAGAAACATAATCTT
GTCGCTGGCCGAGGCCGGATTTTTCCGACCTCGGTGGAGCGATAGAATTATGGATGAGACTGCCGGTGCAATAGCCAAGA
TTACGAAGGGCGGGGCCGACACTAACAAGCAGCGTTCCGCAATGGAGCGCGCTTTCCCCGAAGCATGCGTTACTGGGTAT
GCTGGTCTTGAAGCCGGTCTAGAGTTGCCTGATCCTGATGACCGCCATGTTCTTGCTGCGGCGATCACAACATCCGCTCA
GGTCATTGTGACGGAAAACCTTAAGGATTTCCCAAGCGAAGCACTCGTCCCTTTTGACATCGATGCAATCTCGGCCGACG
AGTTTATTTCTGATGCAATCGAACTTGACCCACTCGCAGCTGTAGTTGCCCTGCGGAAAATGCGTGAGCGGTTCAAAAAT
CCTGATATGGACGCCGAAGCATTATTGCAGCGGATCAAGGCTCGAAAGCTATTTCAAACCGCTGAAATTTTGCACGAATA
CGTAGAGCTACTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9057.45 Da        Isoelectric Point: 4.5230

>AT156237 WP_126680804.1 NZ_CP053191:c213406-213167 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVSPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT156237 NZ_CP069004:128530-128988 [Sulfitobacter mediterraneus]
ATGCAAGCAAAAGAAGCGTTCGCAGAACGTTTGCCGGATCAGGTTGAAATTGAAAATGCTGACAGTCTTCGCCGAATCCT
TGCCTCGCAAGTGAACGGTGATGAGGCAGTTGAGCTGAGCCTGGCACTTGGTAAGAAACAGATCGAACCGGTTACGTTGG
CCCCAGCCCTCGCTGCATCCTTGATGGAGTTGTTGCGGTTGGTGTCAAGCGGCAGAGGGTTCCGGATGATCCCTGTGGAT
GCAGAGTTGACCACTCAGCAAGCGGCCGATTTATTGAATGTGTCGCGCCCACACCTCGTGAAACTTCTAGAAGAAGGGGA
AATCGCCTTCTTCAAAACAGGTCGCCATCGCCGTGTGAAAGCAGCAGATCTGTTTGAATACAAAAAGAAACGCGACTCTG
ATCGCTCTGACGCACTGTCTGACCTTGCCGCGATGGACATGGAGAACGATCTTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure

References