Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3790189..3790846 Replicon chromosome
Accession NZ_CP053190
Organism Enterobacter hormaechei strain EGYMCRVIM

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HK406_RS18240 Protein ID WP_022649305.1
Coordinates 3790189..3790599 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HK406_RS18245 Protein ID WP_003863437.1
Coordinates 3790580..3790846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK406_RS18220 3786187..3787920 - 1734 WP_023314793.1 single-stranded-DNA-specific exonuclease RecJ -
HK406_RS18225 3787926..3788639 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HK406_RS18230 3788668..3789564 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HK406_RS18235 3789666..3790187 + 522 WP_003863440.1 flavodoxin FldB -
HK406_RS18240 3790189..3790599 - 411 WP_022649305.1 protein YgfX Toxin
HK406_RS18245 3790580..3790846 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HK406_RS18250 3791141..3792121 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
HK406_RS18255 3792207..3792866 - 660 WP_003863433.1 hemolysin III family protein -
HK406_RS18260 3793133..3793864 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
HK406_RS18265 3793981..3795414 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T156235 WP_022649305.1 NZ_CP053190:c3790599-3790189 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T156235 NZ_CP068998:c758801-758520 [Sulfitobacter mediterraneus]
ATGATTGGAAGCACACGGGGTAAACTCGCTGCTCAAGCTATGAAAGGTAAGTTTGGCAAAGGCTTTCCCAGCGACCTTGT
AAAACGCACCAGAGCCATCCTCACAGCGCTTGATGCTGCGACCTTGGTGGAAGACTTACGCTTTCCGCCGGGCAATCATC
TGGAAGAACTCAAGGGAGATCGGACCGGTCAACATTCCGTCCGTATCAACCAAAAATGGCGGATCTGTTTTGTGTGGACG
CCGAGCGGCCCCACTGACGTTGAAATTGTTGATTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT156235 WP_003863437.1 NZ_CP053190:c3790846-3790580 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT156235 NZ_CP068998:c758508-758218 [Sulfitobacter mediterraneus]
GTGAGCTTGCTTGAAAACCCGATGCACCCCGGCGAAGTTCTCAGGGAGCTGTATCTCGATCCACTTGATTTGGGTGCTAT
CGCGCTGGCCCGTCGTTTGGCCGTGCCACGCACCCGGATTGAACGGCTGGTCAAAGGTGTGACCAATATGACCCCTGACA
CAGCTTTGCGGCTTGCGCGAGCCTTCGGAACAACGCCCGCATACTGGATGAATTTGCAGACCAATTACGATATGGCCCTG
GCGGCTAAAAAGGTCGATGTGTCCAGCATTGAACCGCTTAGTGCAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References