Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2360614..2361353 Replicon chromosome
Accession NZ_CP053190
Organism Enterobacter hormaechei strain EGYMCRVIM

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HK406_RS11535 Protein ID WP_109948803.1
Coordinates 2360614..2361099 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HK406_RS11540 Protein ID WP_109948802.1
Coordinates 2361087..2361353 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK406_RS11520 2356026..2357513 - 1488 WP_045382033.1 UbiD family decarboxylase -
HK406_RS11525 2357771..2358652 + 882 WP_109948805.1 LysR family transcriptional regulator -
HK406_RS11530 2358744..2359673 - 930 WP_045382036.1 alpha/beta hydrolase -
HK406_RS11535 2360614..2361099 - 486 WP_109948803.1 GNAT family N-acetyltransferase Toxin
HK406_RS11540 2361087..2361353 - 267 WP_109948802.1 DUF1778 domain-containing protein Antitoxin
HK406_RS11545 2361417..2362346 - 930 WP_032658426.1 LysR family transcriptional regulator -
HK406_RS11550 2362476..2363864 + 1389 WP_109948801.1 MFS transporter -
HK406_RS11555 2363886..2364881 - 996 WP_023314163.1 DUF2891 domain-containing protein -
HK406_RS11560 2364891..2365877 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2352199..2361353 9154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17570.26 Da        Isoelectric Point: 9.9658

>T156226 WP_109948803.1 NZ_CP053190:c2361099-2360614 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLTTGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T156226 NZ_CP068985:3759896-3760147 [Nonomuraea coxensis DSM 45129]
ATGAGCGGCTGGCAGGTGCAGGAGGCGAAGCAGCGCTTCAGTGAGGTCGTGCGGCGAGCGGTGAGTGAAGGCCCTCAAGT
GGTGACCCGGCACGGGGAGGAGGTGGCCGTGGTCATCGACATCGCCGAATATCGCCGCCTGCGAGGAGAGACTCCCGACT
TCCGGAAATTTCTCCTGGAAGAACCCGACTGGGACGACGATCTCGATCTTCCCCGCAACCGTGATCTCCCCCGAGAGGTG
GACTTCGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT156226 WP_109948802.1 NZ_CP053190:c2361353-2361087 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMIDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT156226 NZ_CP068985:3760147-3760566 [Nonomuraea coxensis DSM 45129]
ATGGTCGGCTACCTCCTCGACACGAACGTGGTCTCCGAGGTCCGCAAACGAAACGGCAGCCCGTACGTCCGGGACTGGAT
CGGCGGAGCCCATGGGCCCACGCTCTACCTCAGCGCTCTGACCGTCGGAGAGATCCGCTGTGGAGTCGAGCTCCGCAGAC
CCAAGGATCCAGCCCAGGCGACCCTCCTCGAACGCTGGCTGCACAATCTCCACCGGCAGTTCGGCGACCGCATCGTCCCT
GTCACACCGGAGGTCGCGGAGGAATGGGGACGGATGAACGCCGTCCGCCCGCTTCCGACGACGGACGGGTTGATCGCGGC
GACGGCCAGGGTGCACGGGTGGACGCTGGTGAGCAGGAACGTGAAGGATTTCGCGGGCACCGGCGTGTCCGTGGTCAACC
CCTTCGAGCCGCTCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References