Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071474..1072094 Replicon chromosome
Accession NZ_CP053190
Organism Enterobacter hormaechei strain EGYMCRVIM

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HK406_RS05110 Protein ID WP_015571250.1
Coordinates 1071474..1071692 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HK406_RS05115 Protein ID WP_006809850.1
Coordinates 1071720..1072094 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK406_RS05080 1067486..1067746 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HK406_RS05085 1067749..1067889 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HK406_RS05090 1067886..1068596 - 711 WP_045337215.1 GNAT family N-acetyltransferase -
HK406_RS05095 1068698..1070158 + 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
HK406_RS05100 1070130..1070597 - 468 WP_022650495.1 hypothetical protein -
HK406_RS05105 1070714..1071265 - 552 WP_022650496.1 maltose O-acetyltransferase -
HK406_RS05110 1071474..1071692 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HK406_RS05115 1071720..1072094 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HK406_RS05120 1072605..1075751 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
HK406_RS05125 1075774..1076967 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T156224 WP_015571250.1 NZ_CP053190:c1071692-1071474 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T156224 NZ_CP068983:c4595042-4594512 [Paradevosia shaoguanensis]
ATGGCAGAAATAGACGACACGCCGGACCATCCTGAATTGCGACTGTCTGCCCCCATACCTCTGACGACAGAGCATGATCT
TTCGGCGTTCGACTGCGGCGAGCCTGTCCTGAACGACTGGCTGCGCCATCGCGCCTTGAAGAACGAAAGCCGGTTCTCGC
GCACCTATGTCGTGTGCGCAGGCAATCGGGTCGTCGGCTACTTCTGTATCTCGGCCGGATCGGTTGAACGCAGCGCGGCT
CCCGGCAAGATGCGGCGTAACGCGCCCGACCTGATTCCGGTTTCGATTATCGGGCGGCTCGCCGTTAGCCTCGACCATGC
GGGCAAGGGCCTCGGTATGGACCTTTTGTCGGACGCGCTGCGGCGGATTGCAGTCGCCTCGCAAAGCATCGGCATAGGGG
CCGTGCTTGTCCAAGCGAAGGATGAAGCGGCCAAACGCTTCTATCTGCGCTGTGCGGAGTTCATAGAGTATCCCGAGGAC
AGCCGAACGCTGTTCCTGCCCATCGAAACCGTTGTCGCGGGTTTTGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT156224 WP_006809850.1 NZ_CP053190:c1072094-1071720 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT156224 NZ_CP068983:c4595371-4595030 [Paradevosia shaoguanensis]
ATGGCAAAAACACGTCTCGCCCCTTCCGAATCTTCCCGCTCTGCGACCGCTGCCGTCGCCGTGCGCGCCTCTGCGACCGA
CACCAAGGGTAGCATCAATCTGCGTATCGAAACCGGCACGCGCCAGCTCATTGACGATGCTGCGGCAGTCCTCGGCAAGA
CGCGCACCGAGTTCATGGTGGAAAGCGCACGGCGGCAAGCGGTGGATGTGCTGCTCGACCAGCGTTTGTTCACGCTAGAC
TCCGAACGCTACGACGCCTTCATGCAGGCGCTCGACAACCCGCCTGCGCCGGGACCGAAGCTCAAGGCGTTGCTGCGTCG
GACCCCGGCATGGCAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References